KFU. Card publication. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells

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UNCATALYZED CLICK REACTION BETWEEN PHENYL AZIDES AND ACROLEIN: 4-FORMYL-1,2,3-TRIAZOLINES AS &LDQUO;CLICKED&RDQUO; MARKERS FOR VISUALIZATIONS OF EXTRACELLULAR ACROLEIN RELEASED FROM OXIDATIVELY STRESSED CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Saygitbatalova Elena Shiripovna, author

Tanaka Kacunori , author

Bibliographic description in the original language

Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. – 2016. – V. 1. – � 5. – P. 623–632.

Annotation

Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a “click” manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.

Keywords

acrolein, aryl azide, oxidative stress, cell imaging, click chemistry

The name of the journal

ACS SENSORS

URL

http://pubs.acs.org/doi/abs/10.1021/acssensors.6b00122

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=145620&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. – 2016. – V. 1. – � 5. – P. 623–632.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=145620&p_lang=2	ru_RU
dc.description.abstract	ACS SENSORS	ru_RU
dc.description.abstract	Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a “click” manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	aryl azide	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	cell imaging	ru_RU
dc.subject	click chemistry	ru_RU
dc.title	Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU