KFU. Card publication. TRPC6 channel translocation into phagosomal membrane augments phagosomal function

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FEDERAL UNIVERSITY

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TRPC6 CHANNEL TRANSLOCATION INTO PHAGOSOMAL MEMBRANE AUGMENTS PHAGOSOMAL FUNCTION

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Gabdulkhakova Aida Gabdrakhmanovna, author

Bibliographic description in the original language

Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ. / TRPC6 channel translocation into phagosomal membrane augments phagosomal function / Proc Natl Acad Sci U S A. - 2015 Nov 24;112(47):E6486-95. doi: 10.1073/pnas.1518966112.

Annotation

Proc Natl Acad Sci U S A

Keywords

TRPC6; alveolar macrophage; cystic fibrosis; phagosome; roscovitine

The name of the journal

Proc Natl Acad Sci U S A

URL

http://www.pnas.org/content/112/47/E6486.full.pdf?with-ds=yes

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=144103&p_lang=2

Resource files

File name	Size (MB)	Format
PNAS_2015_Riazanski_E6486_95.pdf	3,93	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gabdulkhakova Aida Gabdrakhmanovna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ. / TRPC6 channel translocation into phagosomal membrane augments phagosomal function / Proc Natl Acad Sci U S A. - 2015 Nov 24;112(47):E6486-95. doi: 10.1073/pnas.1518966112.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=144103&p_lang=2	ru_RU
dc.description.abstract	Proc Natl Acad Sci U S A	ru_RU
dc.description.abstract	Defects in the innate immune system in the lung with attendant bacterial infections contribute to lung tissue damage, respiratory insufficiency, and ultimately death in the pathogenesis of cystic fibrosis (CF). Professional phagocytes, including alveolar macrophages (AMs), have specialized pathways that ensure efficient killing of pathogens in phagosomes. Phagosomal acidification facilitates the optimal functioning of degradative enzymes, ultimately contributing to bacterial killing. Generation of low organellar pH is primarily driven by the V-ATPases, proton pumps that use cytoplasmic ATP to load H(+) into the organelle. Critical to phagosomal acidification are various channels derived from the plasma membrane, including the anion channel cystic fibrosis transmembrane conductance regulator, which shunt the transmembrane potential generated by movement of protons. Here we show that the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the AM also functions t	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	TRPC6 channel translocation into phagosomal membrane augments phagosomal function	ru_RU
dc.type	Articles in international journals and collections	ru_RU