KFU. Card publication. CHOLINERGIC REGULATION OF THE DEVELOPING HEART CONTRACTILITY

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CHOLINERGIC REGULATION OF THE DEVELOPING HEART CONTRACTILITY

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

английский

Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Bibliographic description in the original language

Kuptsova A.M. CHOLINERGIC REGULATION OF THE DEVELOPING HEART CONTRACTILITY / A.M. Kuptsova, N.I. Ziyatdinova, R.G. Biktemirova, T.L. Zevfirov // International Journal of Pharmacy & Technology. - 2016. - Vol. 8. - Issue No.3 - P. 14999-15007

Annotation

The activity of the sympathetic and parasympathetic divisions of the autonomic nervous system changes with aging. The researchers suggest that the changes in the heart activity are associated with the restructuring of the sympatheticparasympathetic interactions of the receptor systems in the heart. Our paper describes periods of postnatal ontogenesis associated with the formation of the sympathetic cardiac innervation. The study was conducted in vitro with the use of Power Lab (AD Instruments,Australia) device on the strips of atrial and ventricular myocardium of rats aged 20,8,6,3 and 1 weeks. The obtained results indicate that in all age groups studied the cholinoreceptor agonist – carbachol,on the background of different concentrations of a non-selective blocker of muscarinic cholinergic receptors – atropine,inhibits the inotropy of the atrial and ventricular myocardium. At the same time,the dynamics of myocardial contractility is age dependent. The findings suggest that during post

Keywords

heart, inotropy, muscarinic cholinergic receptors, postnatal ontogenesis

The name of the journal

International Journal of Pharmacy & Technology

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=143150&p_lang=2

Resource files

File name	Size (MB)	Format
CHOLINERGIC_REGULATION_OF_THE_DEVELOPING_HEART_CONTRACTILITY_2016.pdf	0,47	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Kuptsova A.M. CHOLINERGIC REGULATION OF THE DEVELOPING HEART CONTRACTILITY / A.M. Kuptsova, N.I. Ziyatdinova, R.G. Biktemirova, T.L. Zevfirov // International Journal of Pharmacy & Technology. - 2016. - Vol. 8. - Issue No.3 - P. 14999-15007	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=143150&p_lang=2	ru_RU
dc.description.abstract	International Journal of Pharmacy & Technology	ru_RU
dc.description.abstract	The activity of the sympathetic and parasympathetic divisions of the autonomic nervous system changes with aging. The researchers suggest that the changes in the heart activity are associated with the restructuring of the sympatheticparasympathetic interactions of the receptor systems in the heart. Our paper describes periods of postnatal ontogenesis associated with the formation of the sympathetic cardiac innervation. The study was conducted in vitro with the use of Power Lab (AD Instruments,Australia) device on the strips of atrial and ventricular myocardium of rats aged 20,8,6,3 and 1 weeks. The obtained results indicate that in all age groups studied the cholinoreceptor agonist – carbachol,on the background of different concentrations of a non-selective blocker of muscarinic cholinergic receptors – atropine,inhibits the inotropy of the atrial and ventricular myocardium. At the same time,the dynamics of myocardial contractility is age dependent. The findings suggest that during post	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	heart	ru_RU
dc.subject	inotropy	ru_RU
dc.subject	muscarinic cholinergic receptors	ru_RU
dc.subject	postnatal ontogenesis	ru_RU
dc.title	CHOLINERGIC REGULATION OF THE DEVELOPING HEART CONTRACTILITY	ru_RU
dc.type	Articles in international journals and collections	ru_RU