KFU. Card publication. Tuning the non-covalent confinement of Gd(III) complexes in silicananoparticles for high T1-weighted MR imaging capability

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TUNING THE NON-COVALENT CONFINEMENT OF GD(III) COMPLEXES IN SILICANANOPARTICLES FOR HIGH T1-WEIGHTED MR IMAGING CAPABILITY

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Amirov Rustem Rafaelevich, author

Zairov Rustem Ravilevich, author

Stepanov Aleksey Stepanovich, author

Fattakhova Alfiya Nurlimanovna, author

Other authors

Fedorenko Svetlana , author

Bibliographic description in the original language

Fedorenko S.V. Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T1-weighted MR imaging capability/ S.V. Fedorenko, Svetlana L. Grechkina, Asiya R. Mustafina, Kirill V. Kholin, Alexey S. Stepanov, Irek R. Nizameev, Ildus E. Ismaev, Marsil K. Kadirov, Rustem R. Zairova, Alfia N. Fattakhova, Rustem R. Amirov, Svetlana E. Soloveva // Colloids and Surfaces B: Biointerfaces. - 2017. -149. - 243–249.

Annotation

The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres.The results highlight predominant contribution of the complexes located close to silica/water interface tothe relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloidsof the nanoparticles was exemplified by serum bovine albumin.

Keywords

Positive contrast agents, Silica nanoparticles, MRI, Gd(III) complexes, Cytotoxicity

The name of the journal

Colloids and Surfaces B: Biointerfaces

URL

http://dx.doi.org/10.1016/j.colsurfb.2016.10.025

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=141340&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Amirov Rustem Rafaelevich	ru_RU
dc.contributor.author	Zairov Rustem Ravilevich	ru_RU
dc.contributor.author	Stepanov Aleksey Stepanovich	ru_RU
dc.contributor.author	Fattakhova Alfiya Nurlimanovna	ru_RU
dc.contributor.author	Fedorenko Svetlana	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Fedorenko S.V. Tuning the non-covalent confinement of Gd(III) complexes in silica nanoparticles for high T1-weighted MR imaging capability/ S.V. Fedorenko, Svetlana L. Grechkina, Asiya R. Mustafina, Kirill V. Kholin, Alexey S. Stepanov, Irek R. Nizameev, Ildus E. Ismaev, Marsil K. Kadirov, Rustem R. Zairova, Alfia N. Fattakhova, Rustem R. Amirov, Svetlana E. Soloveva // Colloids and Surfaces B: Biointerfaces. - 2017. -149. - 243–249.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=141340&p_lang=2	ru_RU
dc.description.abstract	Colloids and Surfaces B: Biointerfaces	ru_RU
dc.description.abstract	The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5 T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40–55 nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5 T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4.1 to 49.6 mM−1s−1 at 0.47 T when the localization of Gd(III) complexes changes from core to superficial zones of the silica spheres.The results highlight predominant contribution of the complexes located close to silica/water interface tothe relaxivity of the nanoparticles. Low effect of blood proteins on the relaxivity in the aqueous colloidsof the nanoparticles was exemplified by serum bovine albumin.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Positive contrast agents	ru_RU
dc.subject	Silica nanoparticles	ru_RU
dc.subject	MRI	ru_RU
dc.subject	Gd(III) complexes	ru_RU
dc.subject	Cytotoxicity	ru_RU
dc.title	Tuning the non-covalent confinement of Gd(III) complexes in silicananoparticles for high T1-weighted MR imaging capability	ru_RU
dc.type	Articles in international journals and collections	ru_RU