KFU. Card publication. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

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EMERGING ROLES OF THE SINGLE EF-HAND CA2+ SENSOR TESCALCIN IN THE REGULATION OF GENE EXPRESSION, CELL GROWTH AND DIFFERENTIATION

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Kolobynina Kseniya Glebovna, author

Rizvanov Albert Anatolevich, author

Soloveva Valeriya Vladimirovna, author

Other authors

Levay Konstantin , author

Slepak Vladlen , author

Bibliographic description in the original language

Kolobynina K.G. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation / K.G. Kolobynina, V.V. Solovyova, K.Levay, A.A. Rizvanov, V.Z. Slepak // Journal of Cell Science. - 2016. - R. 1-8.

Annotation

Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal

Keywords

CHP3, COP9, GSK3, NHE1, Differentiation, Tescalcin

The name of the journal

Journal of Cell Science

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/104564/10.1242_jcs.191486.pdf?sequence=1&isAllowed=y

URL

http://jcs.biologists.org/content/early/2016/09/08/jcs.191486

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=139113&p_lang=2

Resource files

File name	Size (MB)	Format
10.1242_jcs.191486.pdf	0,46	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kolobynina Kseniya Glebovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Soloveva Valeriya Vladimirovna	ru_RU
dc.contributor.author	Levay Konstantin	ru_RU
dc.contributor.author	Slepak Vladlen	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Kolobynina K.G. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation / K.G. Kolobynina, V.V. Solovyova, K.Levay, A.A. Rizvanov, V.Z. Slepak // Journal of Cell Science. - 2016. - �. 1-8.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=139113&p_lang=2	ru_RU
dc.description.abstract	Journal of Cell Science	ru_RU
dc.description.abstract	Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	CHP3	ru_RU
dc.subject	COP9	ru_RU
dc.subject	GSK3	ru_RU
dc.subject	NHE1	ru_RU
dc.subject	Differentiation	ru_RU
dc.subject	Tescalcin	ru_RU
dc.title	Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation	ru_RU
dc.type	Articles in international journals and collections	ru_RU