KFU. Card publication. Kinetic regulation of multi-ligand binding proteins

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FEDERAL UNIVERSITY

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KINETIC REGULATION OF MULTI-LIGAND BINDING PROTEINS

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

английский

Authors, employees of KFU

Salakhieva Diana Vitalevna, author

Other authors

Chen, Sadreev, Umezawa, Welsh, Kotov Michael, Ildar, Yoshinori, Gavin, Nikolay , author

Bibliographic description in the original language

Kinetic regulation of multi-ligand binding proteins. D.V. Salakhieva, I.I. Sadreev, M.Z.Q. Chen, Y. Umezawa, A.I. Evstifeev, G.I. Welsh, N.V. Kotov // BMC Systems Biology (2016) 10:32. DOI 10.1186/s12918-016-0277-0

Annotation

In this study, a computational analysis of multisite protein kinetics in response to rapid changes in ligand concentrations is presented. Two major physiological scenarios are investigated: i) Ligand concentration is abundant and the ligand-multisite protein binding does not affect free ligand concentration, ii) Ligand concentration is of the same order of magnitude as the interacting multisite protein concentration and does not change. Therefore, buffering effects significantly influence the amounts of free ligands. For each of these scenarios the influence of the number of binding sites, the temporal effects on intermediate apo- and fully saturated conformations and the multisite regulatory effects on target proteins are investigated.

Keywords

Ligand-receptor binding, transient kinetics, calcium, calmodulin.

The name of the journal

BMC Syst. Biol.

URL

http://doi:10.1186/s12918-016-0277-0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=139051&p_lang=2

Resource files

File name	Size (MB)	Format
Kinetic_regulation_of_multi_ligand_binding_proteins_BMC.pdf	2,16	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Salakhieva Diana Vitalevna	ru_RU
dc.contributor.author	Chen, Sadreev, Umezawa, Welsh, Kotov Michael, Ildar, Yoshinori, Gavin, Nikolay	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Kinetic regulation of multi-ligand binding proteins. D.V. Salakhieva, I.I. Sadreev, M.Z.Q. Chen, Y. Umezawa, A.I. Evstifeev, G.I. Welsh, N.V. Kotov // BMC Systems Biology (2016) 10:32. DOI 10.1186/s12918-016-0277-0	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=139051&p_lang=2	ru_RU
dc.description.abstract	BMC Syst. Biol.	ru_RU
dc.description.abstract	In this study, a computational analysis of multisite protein kinetics in response to rapid changes in ligand concentrations is presented. Two major physiological scenarios are investigated: i) Ligand concentration is abundant and the ligand-multisite protein binding does not affect free ligand concentration, ii) Ligand concentration is of the same order of magnitude as the interacting multisite protein concentration and does not change. Therefore, buffering effects significantly influence the amounts of free ligands. For each of these scenarios the influence of the number of binding sites, the temporal effects on intermediate apo- and fully saturated conformations and the multisite regulatory effects on target proteins are investigated.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Ligand-receptor binding	ru_RU
dc.subject	transient kinetics	ru_RU
dc.subject	calcium	ru_RU
dc.subject	calmodulin.	ru_RU
dc.title	Kinetic regulation of multi-ligand binding proteins	ru_RU
dc.type	Articles in international journals and collections	ru_RU