KFU. Card publication. Anti-radical and cytotoxic activity of polysuccinimide and polyaspartic acid of different molecular weight

KAZAN
FEDERAL UNIVERSITY

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ANTI-RADICAL AND CYTOTOXIC ACTIVITY OF POLYSUCCINIMIDE AND POLYASPARTIC ACID OF DIFFERENT MOLECULAR WEIGHT

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Abdullin Timur Ildarovich, author

Gumerova Dilara Radifovna, author

Ishkaeva Rezeda Anasovna, author

Kamalov Marat Ilyasovich, author

Nizamov Ilyas Saidovich, author

Salakhieva Diana Vitalevna, author

Other authors

Nemeth, Szilagyi Csaba, Andras , author

Bibliographic description in the original language

Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight. D.V. Salakhieva, D.R. Gumerova, R.A. Akhmadishina, M.I. Kamalov, I.S. Nizamov, C. Nemeth, A. Szilágyi, T. I. Abdullin // BioNanoSci. (2016). doi:10.1007/s12668-016-0230-0.

Annotation

Effect of poly(succinimide) (PSI) and poly(aspartic acid) (PASP) on free radical reactions and cell viability was assessed. Molecular weight (MW) of PASPs was determined by static light scattering technique, and found as 3.9 and 8.3 kDa. Among PSIs and PASPs only poly(aspartic acid) with higher MW was found to inhibit formation of hydroxyl-radical in Fenton's reaction, although each polymers studied were not able to eliminate diphenylpicrylhydrazyl radical. PASPs were almost non-toxic for 3T3 fibroblasts and PC-3 cells (IC50 >> 3 mg/mL), whereas PSIs diminished cell viability with different IC50 values depending on cell type and polymer MW. Our preliminary data indicate the MW dependence of bioactivity of L aspartic acid-derived polymers designed as drug carriers and biocompatible materials.

Keywords

Poly(succinimide); poly(aspartic acid); molecular weight; free radicals; cytotoxicity

The name of the journal

BioNanoScience

URL

http://doi:10.1007/s12668-016-0230-0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=139049&p_lang=2

Resource files

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BioNanoScience_10.1007_s12668_016_0230_0.pdf	0,80	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdullin Timur Ildarovich	ru_RU
dc.contributor.author	Gumerova Dilara Radifovna	ru_RU
dc.contributor.author	Ishkaeva Rezeda Anasovna	ru_RU
dc.contributor.author	Kamalov Marat Ilyasovich	ru_RU
dc.contributor.author	Nizamov Ilyas Saidovich	ru_RU
dc.contributor.author	Salakhieva Diana Vitalevna	ru_RU
dc.contributor.author	Nemeth, Szilagyi Csaba, Andras	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Anti-Radical and Cytotoxic Activity of Polysuccinimide and Polyaspartic Acid of Different Molecular Weight. D.V. Salakhieva, D.R. Gumerova, R.A. Akhmadishina, M.I. Kamalov, I.S. Nizamov, C. Nemeth, A. Szilágyi, T. I. Abdullin // BioNanoSci. (2016). doi:10.1007/s12668-016-0230-0.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=139049&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Effect of poly(succinimide) (PSI) and poly(aspartic acid) (PASP) on free radical reactions and cell viability was assessed. Molecular weight (MW) of PASPs was determined by static light scattering technique, and found as 3.9 and 8.3 kDa. Among PSIs and PASPs only poly(aspartic acid) with higher MW was found to inhibit formation of hydroxyl-radical in Fenton's reaction, although each polymers studied were not able to eliminate diphenylpicrylhydrazyl radical. PASPs were almost non-toxic for 3T3 fibroblasts and PC-3 cells (IC50 >> 3 mg/mL), whereas PSIs diminished cell viability with different IC50 values depending on cell type and polymer MW. Our preliminary data indicate the MW dependence of bioactivity of L aspartic acid-derived polymers designed as drug carriers and biocompatible materials.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Anti-radical and cytotoxic activity of polysuccinimide and polyaspartic acid of different molecular weight	ru_RU
dc.type	Articles in international journals and collections	ru_RU