KFU. Card publication. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms

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FEDERAL UNIVERSITY

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2(5H)-FURANONE DERIVATIVES AS INHIBITORS OF STAPHYLOCOCCAL BIOFILMS

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

английский

Authors, employees of KFU

Kayumov Ayrat Rashitovich, author

Kurbangalieva Almira Rafaelovna, author

Latypova Liliya Zinnurovna, author

Trizna Elena Yurevna, author

Other authors

Bogachev Mikhail Igorevich, author

Authors, postgraduates KFU

Trizna Elena Yurevna, postgraduate kfu

Bibliographic description in the original language

Trizna E. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms / E. Trizna, L. Latypova, A. Kurbangalieva, M. Bogachev, A. Kayumov // BioNanoScience. - 2016. DOI: 10.1007/s12668-016-0258-1.

Annotation

The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials. Here, we report the effect of four novel 2(5H)-furanone derivatives on the cell growth and biofilm formation by these microorganisms. Using the differential fluorescence staining of viable and dead cells, we demonstrated that furanones increase the antibacterial efficacy of chloramphenicol against both biofilm-embedded S. aureus and S. epidermidis with F35 being the most efficient compound, probably by increasing the accessibility of cells against antimicrobials. Compounds F6, F8, and F83 inhibited the biofilm formation at concentrations of 2.5–10 μg/ml, although exhibiting high cytotoxicity for human skin fibroblasts with CC50 of 0.5–1.1 μg/ml. F35 demonstrated minimal biofilm inhibition concentration of 10 μg/ml, while its cytotoxicity was ten times lower than that of the other compounds (

Keywords

Antibacterial activity, Biofilms, S. aureus, S. epidermidis, 2(5H)-furanones, Unsaturated lactones

The name of the journal

BioNanoScience

URL

https://www.researchgate.net/publication/307555580_25H-Furanone_Derivatives_as_Inhibitors_of_Staphylococcal_Biofilms

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=138242&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Latypova Liliya Zinnurovna	ru_RU
dc.contributor.author	Trizna Elena Yurevna	ru_RU
dc.contributor.author	Bogachev Mikhail Igorevich	ru_RU
dc.contributor.author	Trizna Elena Yurevna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Trizna E. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms / E. Trizna, L. Latypova, A. Kurbangalieva, M. Bogachev, A. Kayumov // BioNanoScience. - 2016. DOI: 10.1007/s12668-016-0258-1.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=138242&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials. Here, we report the effect of four novel 2(5H)-furanone derivatives on the cell growth and biofilm formation by these microorganisms. Using the differential fluorescence staining of viable and dead cells, we demonstrated that furanones increase the antibacterial efficacy of chloramphenicol against both biofilm-embedded S. aureus and S. epidermidis with F35 being the most efficient compound, probably by increasing the accessibility of cells against antimicrobials. Compounds F6, F8, and F83 inhibited the biofilm formation at concentrations of 2.5–10 μg/ml, although exhibiting high cytotoxicity for human skin fibroblasts with CC50 of 0.5–1.1 μg/ml. F35 demonstrated minimal biofilm inhibition concentration of 10 μg/ml, while its cytotoxicity was ten times lower than that of the other compounds (	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Antibacterial activity	ru_RU
dc.subject	Biofilms	ru_RU
dc.subject	S. aureus	ru_RU
dc.subject	S. epidermidis	ru_RU
dc.subject	2(5H)-furanones	ru_RU
dc.subject	Unsaturated lactones	ru_RU
dc.title	2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms	ru_RU
dc.type	Articles in international journals and collections	ru_RU