Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
ROLE OF PURINOCEPTORS AND NPY-RECEPTORS IN THE REGULATION OF RAT HEART IN POSTNATAL ONTOGENESIS
Form of presentationArticles in international journals and collections
Year of publication2016
Языканглийский
  • Anikina Tatyana Andreevna, author
  • Zverev Aleksey Anatolevich, author
  • Zefirov Timur Lvovich, author
  • Krylova Alevtina Vasilevna, author
  • Bibliographic description in the original language Zverev A.A. Role of purinoceptors and npy-receptors in the regulation of rat heart in postnatal ontogenesis / A.A. Zverev, T.A. Anikina, A.V. Krulova, T.L. Zefirov // International Journal of Pharmacy and Technology. - 2016. - Vol.8. - № 2. - P.14592-14598.
    Annotation ATP and neuropeptide Y are present in central and peripheral nervous systems. Being in neurons in conjunction with noradrenaline and acetylcholine they act on own receptors, strengthening or weakening major mediator effects. ATP, neuropeptide Y and their analogues were studied on the myocardial contractility of atria and ventricles of rats during an early postnatal ontogenesis. ATP and its persistent analogues increase the strength of myocardial contractions, acting through its own P2 receptors. The positive inotropic effect confirms their participation in the myocardium contraction among growing animals by the addition of NPY receptor agonists. During the early stages of postnatal ontogenesis, in terms of sympathetic and parasympathetic regulatory effects on heart immaturity, its receptor system, different mechanisms of cotransmitter influence pn the effects of the major mediators are possible. ? 2016, International Journal of Pharmacy and Technology
    Keywords ATP; Contractility; Neuropeptide Y; Ontogenesis; Rat
    The name of the journal International journal of Pharmacy and Technology
    On-line resource for training course http://dspace.kpfu.ru/xmlui/bitstream/handle/net/105834/Doc1.pdf?sequence=1&isAllowed=y
    URL https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978468655&partnerID=40&md5=49c53b3601d5237b77d8a75e14ceccc5
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