KFU. Card publication. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-

KAZAN
FEDERAL UNIVERSITY

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SENSING ACTIVITY OF CHOLINESTERASES THROUGH A LUMINESCENCE RESPONSE OF THE HEXARHENIUM CLUSTER COMPLEX [{RE6S8}(OH)6]4-

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Masson Patrik Ivon Moris , author

Petrov Konstantin Aleksandrovich, author

Bibliographic description in the original language

Elistratova J.G. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-/ J.G. Elistratova, A.R. Mustafina,K .A. Brylev, K.A. Petrov, M.A. Shestopalov, Y.V. Mironov, V.M. Babaev, I.K. Rizvanov, P. Masson, O.G. Sinyashin // Analyst. - 2016. - Vol.141, Is.13. - P.4204-4210.

Annotation

he present work describes a new method to sense cholinesterase-catalyzed hydrolysis of acetylcholine (ACh) through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-. A proton released from acetylcholinesterase (AChE)- or butyrylcholinesterase (BuChE)-catalyzed hydrolysis of ACh results in time-resolved sensitization of cluster-centered luminescence. The sensitization results from protonation of apical hydroxo-groups of the cluster complex. The protonation is affected by a counter ion effect. Thus, optimal conditions for adequate sensing of acetic acid produced by ACh hydrolysis are highlighted. Time-resolved luminescence and pH measurements under conditions of AChE-catalyzed hydrolysis of ACh show a good correlation between the cluster-centered luminescence and pH-induced inhibition of AChE. The inhibition is not significant within the first two minutes of ACh hydrolysis. Thus, the luminescence response measured within two minutes is dependent on both substrat

Keywords

Acetylcholinesterase, hexarhenium cluster complex [{Re6S8}(OH)6]4-

The name of the journal

Analyst

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976448483&partnerID=40&md5=1719df423c629316604f5ec2a11a75cd

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=136571&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Masson Patrik Ivon Moris	ru_RU
dc.contributor.author	Petrov Konstantin Aleksandrovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Elistratova J.G. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-/ J.G. Elistratova, A.R. Mustafina,K .A. Brylev, K.A. Petrov, M.A. Shestopalov, Y.V. Mironov, V.M. Babaev, I.K. Rizvanov, P. Masson, O.G. Sinyashin // Analyst. - 2016. - Vol.141, Is.13. - P.4204-4210.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=136571&p_lang=2	ru_RU
dc.description.abstract	Analyst	ru_RU
dc.description.abstract	he present work describes a new method to sense cholinesterase-catalyzed hydrolysis of acetylcholine (ACh) through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-. A proton released from acetylcholinesterase (AChE)- or butyrylcholinesterase (BuChE)-catalyzed hydrolysis of ACh results in time-resolved sensitization of cluster-centered luminescence. The sensitization results from protonation of apical hydroxo-groups of the cluster complex. The protonation is affected by a counter ion effect. Thus, optimal conditions for adequate sensing of acetic acid produced by ACh hydrolysis are highlighted. Time-resolved luminescence and pH measurements under conditions of AChE-catalyzed hydrolysis of ACh show a good correlation between the cluster-centered luminescence and pH-induced inhibition of AChE. The inhibition is not significant within the first two minutes of ACh hydrolysis. Thus, the luminescence response measured within two minutes is dependent on both substrat	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acetylcholinesterase	ru_RU
dc.subject	hexarhenium cluster complex [{Re6S8}(OH)6]4-	ru_RU
dc.title	Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-	ru_RU
dc.type	Articles in international journals and collections	ru_RU