Form of presentation | Articles in international journals and collections |
Year of publication | 2015 |
Язык | английский |
|
Nikolskiy Evgeniy Evgenevich, author
Petrov Konstantin Aleksandrovich, author
|
Bibliographic description in the original language |
Proskurina S.E. Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice / S.E. Proskurina, K.A. Petrov, A.D. Kharlamova, E.Krejci, E.E. Nikolsky // Genes and Cells, Volume 10, Issue 4, 1 December 2015, Pages 60-62 |
Annotation |
Previously it was shown that activation of NMDA receptors at neuromuscular junction can enhance nitric oxide (NO) production. NO, in turn, able to inhibit synaptic acetylcholinesterase activity and increases amplitude of synaptic responses. In this study we tested a hypothesis that molecular form of acetylcholinesterase anchored in plasma membrane could be more sensitive to endogenous NO inhibition than molecular form of acetylcholinesterase located on basal lamina. Experiments were performed on extensor digitorum longus of (-/-) PRiMA, (-/-) ColQ and wild type mice. After application of NMDA receptors agonists (glutamate and glycine) amplitude and decay time of miniature endplate potentials did not change in synapses of PRiMA or ColQ knock-out mice. Obtained results show that nitric oxide production owing to the activation of enzyme NO-synthase |
Keywords |
Acetylcholinesterase; Glutamate; Neuromuscular synapse; Nitric oxide; NMDA receptor |
The name of the journal |
Genes and Cells
|
URL |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84962217184&partnerID=40&md5=6fa36ad927f5c8bfa69e257557ecf429 |
Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=136024&p_lang=2 |
Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Nikolskiy Evgeniy Evgenevich |
ru_RU |
dc.contributor.author |
Petrov Konstantin Aleksandrovich |
ru_RU |
dc.date.accessioned |
2015-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2015-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2015 |
ru_RU |
dc.identifier.citation |
Proskurina S.E. Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice / S.E. Proskurina, K.A. Petrov, A.D. Kharlamova, E.Krejci, E.E. Nikolsky // Genes and Cells, Volume 10, Issue 4, 1 December 2015, Pages 60-62 |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=136024&p_lang=2 |
ru_RU |
dc.description.abstract |
Genes and Cells |
ru_RU |
dc.description.abstract |
Previously it was shown that activation of NMDA receptors at neuromuscular junction can enhance nitric oxide (NO) production. NO, in turn, able to inhibit synaptic acetylcholinesterase activity and increases amplitude of synaptic responses. In this study we tested a hypothesis that molecular form of acetylcholinesterase anchored in plasma membrane could be more sensitive to endogenous NO inhibition than molecular form of acetylcholinesterase located on basal lamina. Experiments were performed on extensor digitorum longus of (-/-) PRiMA, (-/-) ColQ and wild type mice. After application of NMDA receptors agonists (glutamate and glycine) amplitude and decay time of miniature endplate potentials did not change in synapses of PRiMA or ColQ knock-out mice. Obtained results show that nitric oxide production owing to the activation of enzyme NO-synthase |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
|
ru_RU |
dc.title |
Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice |
ru_RU |
dc.type |
Articles in international journals and collections |
ru_RU |
|