KFU. Card publication. GABAergic Synchronization in Epilepsy

KAZAN
FEDERAL UNIVERSITY

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GABAERGIC SYNCHRONIZATION IN EPILEPSY

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

английский

Authors, employees of KFU

Khazipov Rustem Narimanovich, author

Bibliographic description in the original language

Khazipov R. GABAergic Synchronization in Epilepsy / R. Khazipov // Cold Spring Harb Perspect Med. - Vol. 6. - № 2. - R. 1-13.

Annotation

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the cerebral cortex. GABAergic inhibition enables synchronization of activity in cortical networks, and contributes to generation of variety of brain activity patterns. In relation to epilepsy, GABAergic inhibition has been traditionally viewed as the main mechanism counterbalancing glutamatergic excitation and preventing hypersynchronous neuronal discharges. Indeed, deficits in GABAergic functions most commonly result in a hyperexcitable epileptic state, and many of the currently used antiepileptic drugs act through enhancement of GABAergic functions. However, a number of observations show that some epileptiform activity patterns involve synchronization by GABAergic mechanisms. These include two main categories that will be reviewed here: (1) synchronization of epileptiform oscillations based on GABAergic inhibition, and (2) epileptiform events driven by depolarizing and excitatory GABA. The conclusion is reached th

Keywords

GABA, epilepsy, development

The name of the journal

Cold Spring Harb Perspect Med

URL

http://perspectivesinmedicine.cshlp.org/cgi/pmidlookup?view=long&pmid=26747834

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135716&p_lang=2

Resource files

File name	Size (MB)	Format
Khazipov_Cold_Spring_Harb_Perspect_Med_2016_Khazipov_cshperspect.a022764.pdf	0,74	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Khazipov Rustem Narimanovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Khazipov R. GABAergic Synchronization in Epilepsy / R. Khazipov // Cold Spring Harb Perspect Med. - Vol. 6. - № 2. - Р. 1-13.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135716&p_lang=2	ru_RU
dc.description.abstract	Cold Spring Harb Perspect Med	ru_RU
dc.description.abstract	γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the cerebral cortex. GABAergic inhibition enables synchronization of activity in cortical networks, and contributes to generation of variety of brain activity patterns. In relation to epilepsy, GABAergic inhibition has been traditionally viewed as the main mechanism counterbalancing glutamatergic excitation and preventing hypersynchronous neuronal discharges. Indeed, deficits in GABAergic functions most commonly result in a hyperexcitable epileptic state, and many of the currently used antiepileptic drugs act through enhancement of GABAergic functions. However, a number of observations show that some epileptiform activity patterns involve synchronization by GABAergic mechanisms. These include two main categories that will be reviewed here: (1) synchronization of epileptiform oscillations based on GABAergic inhibition, and (2) epileptiform events driven by depolarizing and excitatory GABA. The conclusion is reached th	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	GABA	ru_RU
dc.subject	epilepsy	ru_RU
dc.subject	development	ru_RU
dc.title	GABAergic Synchronization in Epilepsy	ru_RU
dc.type	Articles in international journals and collections	ru_RU