KFU. Card publication. Exclusive formation of imino[4+4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators

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EXCLUSIVE FORMATION OF IMINO[4+4]CYCLOADDITION PRODUCTS WITH BIOLOGICALLY RELEVANT AMINES: PLAUSIBLE CANDIDATES FOR ACROLEIN BIOMARKERS AND BIOFUNCTIONAL MODULATORS

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Saygitbatalova Elena Shiripovna, author

Tanaka Kacunori , author

Authors, postgraduates KFU

Saygitbatalova Elena Shiripovna, postgraduate kfu

Bibliographic description in the original language

Tsutsui A. Exclusive formation of imino [4+4] cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators / A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka // Med. Chem. Commun. – 2015. – V. 6. – P. 431–436.

Annotation

We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]-nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress.

Keywords

acrolein, 2,6,9-triazabicyclo[3.3.1]nonanes, 1,5-diazacyclooctanes, oxidative stress

The name of the journal

Medicinal Chemical Communications

URL

http://pubs.rsc.org/en/content/articlelanding/2015/md/c4md00383g#!divAbstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135638&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Tsutsui A. Exclusive formation of imino [4+4] cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators / A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka // Med. Chem. Commun. – 2015. – V. 6. – P. 431–436.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135638&p_lang=2	ru_RU
dc.description.abstract	Medicinal Chemical Communications	ru_RU
dc.description.abstract	We synthetically demonstrate that eight-membered heterocycles, namely, 2,6,9-triazabicyclo[3.3.1]-nonanes and 1,5-diazacyclooctanes, are the exclusive products of the reaction of acrolein with biologically relevant amines via an imino[4 + 4]cycloaddition. These compounds are produced in much higher amounts and efficiencies than the acrolein biomarker in current use, 3-formyl-3,4-dehydropiperidine (FDP). Our results not only indicate that eight-membered heterocycles may potentially be used as new biomarkers, but also strongly suggest the involvement of these heterocycles in various important biological phenomena, e.g., an acrolein-mediated mechanism underlying oxidative stress.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	2	ru_RU
dc.subject	6	ru_RU
dc.subject	9-triazabicyclo[3.3.1]nonanes	ru_RU
dc.subject	1	ru_RU
dc.subject	5-diazacyclooctanes	ru_RU
dc.subject	oxidative stress	ru_RU
dc.title	Exclusive formation of imino[4+4]cycloaddition products with biologically relevant amines: plausible candidates for acrolein biomarkers and biofunctional modulators	ru_RU
dc.type	Articles in international journals and collections	ru_RU