KFU. Card publication. Cell surface and in vivo interaction of dendrimeric N-glycoclusters

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

CELL SURFACE AND IN VIVO INTERACTION OF DENDRIMERIC N-GLYCOCLUSTERS

Form of presentation

Articles in international journals and collections

Year of publication

2015

Язык

английский

Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Tanaka Kacunori , author

Bibliographic description in the original language

Taichi M. Cell surface and in vivo interaction of dendrimeric N-glycoclusters / M. Taichi, S. Kitazume, K. K. H. Vong, R. Imamaki, A. Kurbangalieva, N. Taniguchi, K. Tanaka // Glycoconj. J. – 2015. – V. 32. – P. 497–503.

Annotation

While many examples have been reported that glycoclusters interact with target lectins more strongly than single molecules of glycans, through multivalency effects, literature examples to support lectin interactions/modulations on cell surface and in live animals is quite rare. Our N-glycoclusters, which were efficiently prepared by immobilizing 16 molecules of the asparagine-linked glycans (N-glycans) onto a lysine-based dendron template through histidine-mediated Huisgen cycloaddition, were shown to efficiently detect platelet endothelial cell adhesion molecule (PECAM) on human umbilical vein endothelial cells (HUVEC) as a α(2-6)-sialylated oligosaccharides recognizing lectin. Furthermore, the identity of the N-glycans on our N-glycoclusters allowed kontrol over organ-selective accumulation and serum clearance properties when intravenously injected into mice.

Keywords

asparagine-linked glycans, dendrimer, platelet endothelial cell adhesion molecule, glycocluster, in vivo imaging, lectin

The name of the journal

Glycoconjugate Journal

URL

http://link.springer.com/article/10.1007/s10719-015-9594-6

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135636&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Taichi M. Cell surface and in vivo interaction of dendrimeric N-glycoclusters / M. Taichi, S. Kitazume, K. K. H. Vong, R. Imamaki, A. Kurbangalieva, N. Taniguchi, K. Tanaka // Glycoconj. J. – 2015. – V. 32. – P. 497–503.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135636&p_lang=2	ru_RU
dc.description.abstract	Glycoconjugate Journal	ru_RU
dc.description.abstract	While many examples have been reported that glycoclusters interact with target lectins more strongly than single molecules of glycans, through multivalency effects, literature examples to support lectin interactions/modulations on cell surface and in live animals is quite rare. Our N-glycoclusters, which were efficiently prepared by immobilizing 16 molecules of the asparagine-linked glycans (N-glycans) onto a lysine-based dendron template through histidine-mediated Huisgen cycloaddition, were shown to efficiently detect platelet endothelial cell adhesion molecule (PECAM) on human umbilical vein endothelial cells (HUVEC) as a α(2-6)-sialylated oligosaccharides recognizing lectin. Furthermore, the identity of the N-glycans on our N-glycoclusters allowed kontrol over organ-selective accumulation and serum clearance properties when intravenously injected into mice.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	asparagine-linked glycans	ru_RU
dc.subject	dendrimer	ru_RU
dc.subject	platelet endothelial cell adhesion molecule	ru_RU
dc.subject	glycocluster	ru_RU
dc.subject	in vivo imaging	ru_RU
dc.subject	lectin	ru_RU
dc.title	Cell surface and in vivo interaction of dendrimeric N-glycoclusters	ru_RU
dc.type	Articles in international journals and collections	ru_RU