KFU. Card publication. Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting

KAZAN
FEDERAL UNIVERSITY

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GLYCAN MULTIVALENCY EFFECTS TOWARD ALBUMIN ENABLE N-GLYCAN-DEPENDENT TUMOR TARGETING

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Tanaka Kacunori , author

Bibliographic description in the original language

Ogura A. Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting / A. Ogura, T. Tahara, S. Nozaki, H. Onoe, A. Kurbangalieva, Y. Watanabe, K. Tanaka // Bioorg. Med. Chem. Lett. – 2016. – V. 26. – � 9. – R. 2251–2254.

Annotation

Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing 10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.

Keywords

N-glycan, multivalency effect, A431 tumor, alpha(2,3)-disialoglycan, in vivo molecular imaging

The name of the journal

Bioorganic and Medicinal Chemistry Letters

URL

https://www.scopus.com/inward/record.url?eid=2-s2.0-84962154863&partnerID=40&md5=6ecd9587b54e63ae3f22a3f659f2db29

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135633&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Ogura A. Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting / A. Ogura, T. Tahara, S. Nozaki, H. Onoe, A. Kurbangalieva, Y. Watanabe, K. Tanaka // Bioorg. Med. Chem. Lett. – 2016. – V. 26. – � 9. – �. 2251–2254.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135633&p_lang=2	ru_RU
dc.description.abstract	Bioorganic and Medicinal Chemistry Letters	ru_RU
dc.description.abstract	Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing 10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	N-glycan	ru_RU
dc.subject	multivalency effect	ru_RU
dc.subject	A431 tumor	ru_RU
dc.subject	alpha(2	ru_RU
dc.subject	3)-disialoglycan	ru_RU
dc.subject	in vivo molecular imaging	ru_RU
dc.title	Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting	ru_RU
dc.type	Articles in international journals and collections	ru_RU