| Form of presentation | Articles in Russian journals and collections |
| Year of publication | 2011 |
| Язык | английский |
|
Sitdikova Guzel Faritovna, author
Khaertdinov Nail Nazimovich, author
|
|
Zefirov Andrey Lvovich, author
|
| Bibliographic description in the original language |
Sitdikova G. F. Role of Calcium and Potassium Channels in Effects
of Hydrogen Sulfide on Frog Myocardial Contractility /
G. F. Sitdikova, N. N. Khaertdinov, and A. L. Zefirov // Bulletin of Experimental Biology and Medicine.-2011.-№ 2.- P. 163-166.
|
| Annotation |
The effects of sodium hydrosulfi de NaHS, a donor of hydrogen sulfi de H2S, on the force of muscle contraction were examined on isolated myocardial strips from frog ventricles. NaHS decreased the amplitude of muscle contractions in a dose-dependent manner under normal conditions and during inhibition of Ca channels with nifedipine. In contrast, under conditions of blockade of ATP-dependent potassium channels with glibenclamide, NaHS exerted a positive inotropic effect from the fi rst minute of application. Neither blockade, nor activation of ATP-dependent K-channels with glibenclamide modulated the negative inotropic effect of NaHS. Inhibition of K-channels with tetraethylammonium (TEA) (3, 5, 10 mM) or 4-aminopyridine increased the amplitude of myocardial contractions. Preliminary application of 4-aminopyridine or TEA (3 mM) did not eliminate NaHS-induced negative inotropic effect,
although higher TEA concentrations (5 or 10 mM) prevented it. |
| Keywords |
hydrogen sulfide; frog myocardium; calcium channels; ATP-dependent Kchannels;
voltage-dependent K-channels; Ca-activated K-channels |
| The name of the journal |
Bulletin of Experimental Biology and Medicine
|
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=135015&p_lang=2 |
| Resource files | |
|
|
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Sitdikova Guzel Faritovna |
ru_RU |
| dc.contributor.author |
Khaertdinov Nail Nazimovich |
ru_RU |
| dc.contributor.author |
Zefirov Andrey Lvovich |
ru_RU |
| dc.date.accessioned |
2011-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2011-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2011 |
ru_RU |
| dc.identifier.citation |
Sitdikova G. F. Role of Calcium and Potassium Channels in Effects
of Hydrogen Sulfide on Frog Myocardial Contractility /
G. F. Sitdikova, N. N. Khaertdinov, and A. L. Zefirov // Bulletin of Experimental Biology and Medicine.-2011.-№ 2.- P. 163-166.
|
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=135015&p_lang=2 |
ru_RU |
| dc.description.abstract |
Bulletin of Experimental Biology and Medicine |
ru_RU |
| dc.description.abstract |
The effects of sodium hydrosulfi de NaHS, a donor of hydrogen sulfi de H2S, on the force of muscle contraction were examined on isolated myocardial strips from frog ventricles. NaHS decreased the amplitude of muscle contractions in a dose-dependent manner under normal conditions and during inhibition of Ca channels with nifedipine. In contrast, under conditions of blockade of ATP-dependent potassium channels with glibenclamide, NaHS exerted a positive inotropic effect from the fi rst minute of application. Neither blockade, nor activation of ATP-dependent K-channels with glibenclamide modulated the negative inotropic effect of NaHS. Inhibition of K-channels with tetraethylammonium (TEA) (3, 5, 10 mM) or 4-aminopyridine increased the amplitude of myocardial contractions. Preliminary application of 4-aminopyridine or TEA (3 mM) did not eliminate NaHS-induced negative inotropic effect,
although higher TEA concentrations (5 or 10 mM) prevented it. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Role of Calcium and Potassium Channels in Effects
of Hydrogen Sulfide on Frog Myocardial Contractility |
ru_RU |
| dc.type |
Articles in Russian journals and collections |
ru_RU |
|
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