KFU. Card publication. Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth

KAZAN
FEDERAL UNIVERSITY

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STOMACH CANCER: INTERCONNECTION BETWEEN THE REDOX STATE, ACTIVITY OF MMP-2, MMP-9 AND STAGE OF TUMOR GROWTH

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Gafurov Marat Revgerovich, author

Bibliographic description in the original language

Burlaka A.P, Ganusevich I.I, Gafurov M.R, Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth//Cancer Microenvironment. - 2016. - Vol.9, Is.1. - P.27-32.

Annotation

High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the super

Keywords

Reactive oxygen species (ROS), Matrix metalloproteinases, Stomach cancer, Gastric cancer, Electron spin resonance (ESR), Electron paramagnetic resonance (EPR), Metastasis

The name of the journal

Cancer Microenvironment

URL

http://link.springer.com/article/10.1007/s12307-016-0182-5

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=129842&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gafurov Marat Revgerovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Burlaka A.P, Ganusevich I.I, Gafurov M.R, Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth//Cancer Microenvironment. - 2016. - Vol.9, Is.1. - P.27-32.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=129842&p_lang=2	ru_RU
dc.description.abstract	Cancer Microenvironment	ru_RU
dc.description.abstract	High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the super	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Reactive oxygen species (ROS)	ru_RU
dc.subject	Matrix metalloproteinases	ru_RU
dc.subject	Stomach cancer	ru_RU
dc.subject	Gastric cancer	ru_RU
dc.subject	Electron spin resonance (ESR)	ru_RU
dc.subject	Electron paramagnetic resonance (EPR)	ru_RU
dc.subject	Metastasis	ru_RU
dc.title	Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth	ru_RU
dc.type	Articles in international journals and collections	ru_RU