KFU. Card publication. Камалов, М. И. Неинвазивная актуальным доставки лекарств к спинному мозгу с карбоксильной модифицированный трифункционального сополимера окиси этилена и окиси пропилена / MI Камалов, И.А. Лавров, А. А. Yergeshov, З.Ы. Сираева, ME Балтин, А.А. Ризванов, С.В. Кузнецова, Н. В. Петрова, И.Н. Савина, Т. Абдуллин // коллоидов и поверхностей B: Biointerfaces. - 2016. - V. 140, № 1.

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КАМАЛОВ, М. И. НЕИНВАЗИВНАЯ АКТУАЛЬНЫМ ДОСТАВКИ ЛЕКАРСТВ К СПИННОМУ МОЗГУ С КАРБОКСИЛЬНОЙ МОДИФИЦИРОВАННЫЙ ТРИФУНКЦИОНАЛЬНОГО СОПОЛИМЕРА ОКИСИ ЭТИЛЕНА И ОКИСИ ПРОПИЛЕНА / MI КАМАЛОВ, И.А. ЛАВРОВ, А. А. YERGESHOV, З.Ы. СИРАЕВА, ME БАЛТИН, А.А. РИЗВАНОВ, С.В. КУЗНЕЦОВА, Н. В. ПЕТРОВА, И.Н. САВИНА, Т. АБДУЛЛИН // КОЛЛОИДОВ И ПОВЕРХНОСТЕЙ B: BIOINTERFACES. - 2016. - V. 140, № 1. - С. 196-203

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

русский

Authors, employees of KFU

Abdullin Timur Ildarovich, author

Baltin Maksim Eduardovich, author

Lavrov Igor Aleksandrovich, author

Petrova Natalya Valentinovna, author

Rizvanov Albert Anatolevich, author

Siraeva Zulfira Yunysovna, author

Authors, postgraduates KFU

Baltin Maksim Eduardovich, postgraduate kfu

Ergeshov Abdulla Arslanovich, postgraduate kfu

Bibliographic description in the original language

Marat Kamalov; Igor Lavrov, Ph.D.; Abdulla Ergeshov; Zulfira Siraeva, Ph.D.; Maxim Baltin; Albert Rizvanov, Ph.D.; Svetlana Kuznetcova; Natalia Petrova, Ph.D.; Irina Savina, Ph.D., Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide//Colloids and Surfaces B: Biointerfaces.- 2016. - V. 140, № 1. - S. 196-203

Annotation

In this study the effect of oxidative modification on micellar and drug delivery properties of copolymers of ethylene oxide (EO) and propylene oxide (PO) was investigated. Carboxylated trifunctional copolymers were synthesized in the reaction with chromium(VI) oxide. We found that carboxylation significantly improved the uniformity and stability of polymeric micelles by inhibiting the microphase transition. The cytotoxicity of copolymers was studied in relation to their aggregative state on two cell types (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 in neuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidized block copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. The copolymer was also tested as an enhancer for topical drug delivery to the spinal cord when applied subdurally. The oxidized copolymer facilitated the penetration of rhodamine 123 across spinal cord tissues and increased its intraspinal acc

Keywords

Амфифильные полимеры ;Трифункциональные сополимеры этиленоксида и пропиленоксида ;Окислительная модификация ;мицеллы ;Доставка лекарств ;Нервные клетки ;Спинной мозг ;Травматическое повреждение

The name of the journal

Colloids and Surfaces B: Biointerfaces

URL

http://www.sciencedirect.com/science/article/pii/S0927776515303842

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=127339&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdullin Timur Ildarovich	ru_RU
dc.contributor.author	Baltin Maksim Eduardovich	ru_RU
dc.contributor.author	Lavrov Igor Aleksandrovich	ru_RU
dc.contributor.author	Petrova Natalya Valentinovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Siraeva Zulfira Yunysovna	ru_RU
dc.contributor.author	Baltin Maksim Eduardovich	ru_RU
dc.contributor.author	Ergeshov Abdulla Arslanovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Marat Kamalov; Igor Lavrov, Ph.D.; Abdulla Ergeshov; Zulfira Siraeva, Ph.D.; Maxim Baltin; Albert Rizvanov, Ph.D.; Svetlana Kuznetcova; Natalia Petrova, Ph.D.; Irina Savina, Ph.D., Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide//Colloids and Surfaces B: Biointerfaces.- 2016. - V. 140, № 1. - С. 196-203	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=127339&p_lang=2	ru_RU
dc.description.abstract	Colloids and Surfaces B: Biointerfaces	ru_RU
dc.description.abstract	In this study the effect of oxidative modification on micellar and drug delivery properties of copolymers of ethylene oxide (EO) and propylene oxide (PO) was investigated. Carboxylated trifunctional copolymers were synthesized in the reaction with chromium(VI) oxide. We found that carboxylation significantly improved the uniformity and stability of polymeric micelles by inhibiting the microphase transition. The cytotoxicity of copolymers was studied in relation to their aggregative state on two cell types (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 in neuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidized block copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. The copolymer was also tested as an enhancer for topical drug delivery to the spinal cord when applied subdurally. The oxidized copolymer facilitated the penetration of rhodamine 123 across spinal cord tissues and increased its intraspinal acc	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Камалов, М. И. Неинвазивная актуальным доставки лекарств к спинному мозгу с карбоксильной модифицированный трифункционального сополимера окиси этилена и окиси пропилена / MI Камалов, И.А. Лавров, А. А. Yergeshov, З.Ы. Сираева, ME Балтин, А.А. Ризванов, С.В. Кузнецова, Н. В. Петрова, И.Н. Савина, Т. Абдуллин // коллоидов и поверхностей B: Biointerfaces. - 2016. - V. 140, № 1. - С. 196-203	ru_RU
dc.type	Articles in international journals and collections	ru_RU