KFU. Card publication. Age-dependent action of reactive oxygen species on transmitter release in mammalian neuromuscular junctions

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FEDERAL UNIVERSITY

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AGE-DEPENDENT ACTION OF REACTIVE OXYGEN SPECIES ON TRANSMITTER RELEASE IN MAMMALIAN NEUROMUSCULAR JUNCTIONS

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Valeeva Guzel Ravilevna, author

Nikolskiy Evgeniy Evgenevich, author

Shakirzyanova Anastasiya Vyacheslavovna, author

Other authors

Atalay Mustafa Mustafa, author

Fulle Stefania Fulle, author

Akulov Anton Nikolaevich, author

Giniatullin Artur Raufovich, author

Naumenko Nikolay Vladimirovich, author

Bibliographic description in the original language

Age-dependent action of reactive oxygen species on transmitter release in mammalian neuromuscular junctions / A. Shakirzyanova, G. Valeeva, A. Giniatullin, N. Naumenko, S. Fulle, A. Akulov, M. Atalay, E. Nikolsky, R. Giniatullin // Neurobiology of Aging. - 2016. - V.38. - P.73-81.

Annotation

Neurobiology of Aging

Keywords

Acetylcholine release, neuromuscular, reactive oxygen species, newborn, aging

The name of the journal

Neurobiology of Aging

URL

http://www.neurobiologyofaging.org/article/S0197-4580%2815%2900535-7/abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=124627&p_lang=2

Resource files

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Shakirzyanova_et_al.__2016.pdf	1,16	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Valeeva Guzel Ravilevna	ru_RU
dc.contributor.author	Nikolskiy Evgeniy Evgenevich	ru_RU
dc.contributor.author	Shakirzyanova Anastasiya Vyacheslavovna	ru_RU
dc.contributor.author	Atalay Mustafa Mustafa	ru_RU
dc.contributor.author	Fulle Stefania Fulle	ru_RU
dc.contributor.author	Akulov Anton Nikolaevich	ru_RU
dc.contributor.author	Giniatullin Artur Raufovich	ru_RU
dc.contributor.author	Naumenko Nikolay Vladimirovich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Age-dependent action of reactive oxygen species on transmitter release in mammalian neuromuscular junctions / A. Shakirzyanova, G. Valeeva, A. Giniatullin, N. Naumenko, S. Fulle, A. Akulov, M. Atalay, E. Nikolsky, R. Giniatullin // Neurobiology of Aging. - 2016. - V.38. - P.73-81.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=124627&p_lang=2	ru_RU
dc.description.abstract	Neurobiology of Aging	ru_RU
dc.description.abstract	Neurobiology of Aging	ru_RU
dc.description.abstract	Reactive oxygen species (ROS) are implicated in aging, but the neurobiological mechanisms of ROS actionare not fully understood. Using electrophysiological techniques and biochemical assays, we studied the age-dependent effect of hydrogen peroxide (H2O2) on acetylcholine release in rat diaphragm neuromuscular junctions. H2O2 significantly inhibited both spontaneous (measured as frequency of miniature endplate potentials) and evoked (amplitude of end-plate potentials) transmitter release in adult rats. The inhibitory effect of H2O2 was much stronger in old rats, whereas in newborns tested during the first postnatal week, H2O2 did not affect spontaneous release from nerve endings and potentiated end-plate potentials. Proteinkinase C activation or intracellular Ca2þ elevation restored redox sensitivity of miniature end-plate potentials in newborns. The resistance of neonates to H2O2 inhibition was associated with higher catalase and glutathione peroxidase activities in skeletal muscle.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acetylcholine release	ru_RU
dc.subject	neuromuscular	ru_RU
dc.subject	reactive oxygen species	ru_RU
dc.subject	newborn	ru_RU
dc.subject	aging	ru_RU
dc.title	Age-dependent action of reactive oxygen species on transmitter release in mammalian neuromuscular junctions	ru_RU
dc.type	Articles in international journals and collections	ru_RU