KFU. Card publication. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

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ANTIBACTERIAL EFFECTS OF QUATERNARY BIS-PHOSPHONIUM AND AMMONIUM SALTS OF PYRIDOXINE ON STAPHYLOCOCCUS AUREUS CELLS: A SINGLE BASE HITTING TWO DISTINCT TARGETS?

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Evtyugin Vladimir Gennadevich, author

Kayumov Ayrat Rashitovich, author

Nikitina Elena Vladimirovna, author

Pugachev Mikhail Vladimirovich, author

Fedosimova Svetlana Vladimirovna, author

Shtyrlin Yuriy Grigorevich, author

Other authors

Bogachev Mikhail Igorevich, author

Authors, postgraduates KFU

Kuznecova Svetlana Vladimirovna, postgraduate kfu

Bibliographic description in the original language

Nikitina E.V. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets? / Nikitina E.V., Zeldi M. I., Pugachev M.V., Sapozhnikov S.V., Shtyrlin N.V., Kuznetsova S.V., Evtygin V.E., Bogachev M.I., Kayumov A.R., Shtyrlin Y.G. // World Journal of Microbiology and Biotechnology. - 2016. - V.32, Is.1.

Annotation

We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca2+ ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca2+ ions can successfully impede the membrane Ca2+ ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no e

Keywords

Quaternary phosphonium salts, Quaternary ammonium salts, Pyridoxine, Antibacterial activity, Fluorescent microscopy

The name of the journal

WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

URL

http://link.springer.com/article/10.1007/s11274-015-1969-0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=124017&p_lang=2

Resource files

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Evtyugin Vladimir Gennadevich	ru_RU
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.contributor.author	Nikitina Elena Vladimirovna	ru_RU
dc.contributor.author	Pugachev Mikhail Vladimirovich	ru_RU
dc.contributor.author	Fedosimova Svetlana Vladimirovna	ru_RU
dc.contributor.author	Shtyrlin Yuriy Grigorevich	ru_RU
dc.contributor.author	Bogachev Mikhail Igorevich	ru_RU
dc.contributor.author	Kuznecova Svetlana Vladimirovna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Nikitina E.V. Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets? / Nikitina E.V., Zeldi M. I., Pugachev M.V., Sapozhnikov S.V., Shtyrlin N.V., Kuznetsova S.V., Evtygin V.E., Bogachev M.I., Kayumov A.R., Shtyrlin Y.G. // World Journal of Microbiology and Biotechnology. - 2016. - V.32, Is.1.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=124017&p_lang=2	ru_RU
dc.description.abstract	WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY	ru_RU
dc.description.abstract	We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca2+ ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca2+ ions can successfully impede the membrane Ca2+ ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no e	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Quaternary phosphonium salts	ru_RU
dc.subject	Quaternary ammonium salts	ru_RU
dc.subject	Pyridoxine	ru_RU
dc.subject	Antibacterial activity	ru_RU
dc.subject	Fluorescent microscopy	ru_RU
dc.title	Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?	ru_RU
dc.type	Articles in international journals and collections	ru_RU