KFU. Card publication. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity Against Biofilm-Embedded Staphylococcus Cells.

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NEW DERIVATIVES OF PYRIDOXINE EXHIBIT HIGH ANTIBACTERIAL ACTIVITY AGAINST BIOFILM-EMBEDDED STAPHYLOCOCCUS CELLS.

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Gazizova Guzel Rashitovna, author

Sapozhnikov Sergey Vitalevich, author

Shtyrlin Nikita Valerevich, author

Shtyrlin Yuriy Grigorevich, author

Other authors

Bogachev Mikhail -, author

Authors, postgraduates KFU

Pugachev Mikhail Vladimirovich, postgraduate kfu

Authors, students KFU

Nurieva Aliya Azatovna, author

Trizna Elena Yurevna, author

Bibliographic description in the original language

Kayumov A.R. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity Against Biofilm-Embedded Staphylococcus Cells // A.R. Kayumov, A.A. Nureeva, G. R. Gazizova, M.I. Bogachev, N.V. Shtyrlin, M.V. Pugachev, S.V. Sapozhnikov, Y.G. Shtyrlin // Biomed research international. - 2015.

Annotation

Biomed research international

Keywords

antibacterial activity, biofilms, �ationic biocides, Staphylococcus

The name of the journal

Biomed research international

URL

http://www.hindawi.com/journals/bmri/aip/890968/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=121549&p_lang=2

Resource files

File name	Size (MB)	Format
890968__3_.pdf	1,99	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gazizova Guzel Rashitovna	ru_RU
dc.contributor.author	Sapozhnikov Sergey Vitalevich	ru_RU
dc.contributor.author	Shtyrlin Nikita Valerevich	ru_RU
dc.contributor.author	Shtyrlin Yuriy Grigorevich	ru_RU
dc.contributor.author	Bogachev Mikhail -	ru_RU
dc.contributor.author	Nurieva Aliya Azatovna	ru_RU
dc.contributor.author	Trizna Elena Yurevna	ru_RU
dc.contributor.author	Pugachev Mikhail Vladimirovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Kayumov A.R. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity Against Biofilm-Embedded Staphylococcus Cells // A.R. Kayumov, A.A. Nureeva, G. R. Gazizova, M.I. Bogachev, N.V. Shtyrlin, M.V. Pugachev, S.V. Sapozhnikov, Y.G. Shtyrlin // Biomed research international. - 2015.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=121549&p_lang=2	ru_RU
dc.description.abstract	Biomed research international	ru_RU
dc.description.abstract	Opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on tissues and inorganic surfaces. In the biofilm bacterial cells are embedded in a selfproduced polysaccharide matrix and thereby are inaccessible to biocides, antibiotics or host immune system. Here we show the antibacterial activity of newly synthesized cationic biocides, the quaternary ammonium and bis-phosphonium salts of pyridoxine (vitamin B6) against biofilm-embedded Staphylococci. The derivatives of 6-hydroxymethylpyridoxine were ineffective against biofilm-embedded S. aureus and S. epidermidis at concentrations up to 64 g/ml, although all compounds tested exhibited low MICs (2 g/ml) against planktonic cells. In contrast, the quaternary ammonium salt of pyridoxine (N,N-dimethyl-N-((2,2,8-trimethyl-4H- [1,3]dioxino[4,5-c]pyridin-5-yl)methyl)octan-1-aminium chloride) demonstrated high biocidic activity against both planktonic and biofilm-embedded bacteria. Thus, the	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	antibacterial activity	ru_RU
dc.subject	biofilms	ru_RU
dc.subject	�ationic biocides	ru_RU
dc.subject	Staphylococcus	ru_RU
dc.title	New Derivatives of Pyridoxine Exhibit High Antibacterial Activity Against Biofilm-Embedded Staphylococcus Cells.	ru_RU
dc.type	Articles in international journals and collections	ru_RU