KFU. Card publication. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

EFFECTS OF A HYDROGEN SULFIDE DONOR ON SPONTANEOUS CONTRACTILE ACTIVITY OF RAT STOMACH AND JEJUNUM

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

��

��

Authors, employees of KFU

Sabirullina Guliya Ilnatovna, author

Sitdikova Guzel Faritovna, author

Shafigullin Marat Ulfatovich, author

Other authors

Zefirov Andrey Lvovich, author

Zefirov Ruslan Andreevich, author

Authors, postgraduates KFU

Sabirullina Guliya Ilnatovna, postgraduate kfu

Bibliographic description in the original language

M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - t.157. - �3 - 302-306.

Annotation

We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels.

Keywords

hydrogen sulfi de; smooth muscle cells; stomach; jejunum; potassium channels

The name of the journal

Bulletin of Experimental Biology and Medicine

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=120336&p_lang=2

Resource files

File name	Size (MB)	Format
Shafigullin2014.pdf	0,35	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Sabirullina Guliya Ilnatovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Shafigullin Marat Ulfatovich	ru_RU
dc.contributor.author	Zefirov Andrey Lvovich	ru_RU
dc.contributor.author	Zefirov Ruslan Andreevich	ru_RU
dc.contributor.author	Sabirullina Guliya Ilnatovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - �.157. - �3 - 302-306.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=120336&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU