KFU. Card publication. Computational modelling elucidates the mechanism of ciliary regulation in health and disease / Kotov NV, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV. //BMC Syst Biol. 2011 Sep 15;5:143. doi: 10.1186/1752-0509-5-143.

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COMPUTATIONAL MODELLING ELUCIDATES THE MECHANISM OF CILIARY REGULATION IN HEALTH AND DISEASE / KOTOV NV, BATES DG, GIZATULLINA AN, GILAZIEV B, KHAIRULLIN RN, CHEN MZ, DROZDOV I, UMEZAWA Y, HUNDHAUSEN C, ALEKSANDROV A, YAN XG, SPURGEON SK, SMALES CM, VALEYEV NV. //BMC SYST BIOL. 2011 SEP 15;5:143. DOI: 10.1186/1752-0509-5-143.

Form of presentation

Articles in international journals and collections

Year of publication

2011

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Authors, employees of KFU

Bazanovas Antonina Nikolaevna, author

Kotov Nikolay Viktorovich, author

Other authors

Valeyev Najl Valievich, author

Bibliographic description in the original language

Computational modelling elucidates the mechanism of ciliary regulation in health and disease. Kotov NV1, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV

Annotation

Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex and despite extensive experimental characterization remains poorly understood. We develop a detailed systems model for calcium, membrane potential and cyclic nucleotide-dependent ciliary motility regulation. The model describes the intimate relationship between calcium and potassium ionic concentrations inside and outside of cilia with membrane voltage and, for the first time, describes a novel type of ciliary excitability which plays the major role in ciliary movement regulation. Our model describes a mechanism that allows ciliary excitation to be robust over a wide physiological range of extracellular ionic concentrations. The model predicts the existence of several dynamic modes of ciliary regulation.

Keywords

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The name of the journal

BMC SYSTEMS BIOLOGY

URL

http://www.biomedcentral.com/1752-0509/5/143

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=115066&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bazanovas Antonina Nikolaevna	ru_RU
dc.contributor.author	Kotov Nikolay Viktorovich	ru_RU
dc.contributor.author	Valeyev Najl Valievich	ru_RU
dc.date.accessioned	2011-01-01T00:00:00Z	ru_RU
dc.date.available	2011-01-01T00:00:00Z	ru_RU
dc.date.issued	2011	ru_RU
dc.identifier.citation	Computational modelling elucidates the mechanism of ciliary regulation in health and disease. Kotov NV1, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=115066&p_lang=2	ru_RU
dc.description.abstract	BMC SYSTEMS BIOLOGY	ru_RU
dc.description.abstract	Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex and despite extensive experimental characterization remains poorly understood. We develop a detailed systems model for calcium, membrane potential and cyclic nucleotide-dependent ciliary motility regulation. The model describes the intimate relationship between calcium and potassium ionic concentrations inside and outside of cilia with membrane voltage and, for the first time, describes a novel type of ciliary excitability which plays the major role in ciliary movement regulation. Our model describes a mechanism that allows ciliary excitation to be robust over a wide physiological range of extracellular ionic concentrations. The model predicts the existence of several dynamic modes of ciliary regulation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.title	Computational modelling elucidates the mechanism of ciliary regulation in health and disease / Kotov NV, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV. //BMC Syst Biol. 2011 Sep 15;5:143. doi: 10.1186/1752-0509-5-143.	ru_RU
dc.type	Articles in international journals and collections	ru_RU