KFU. Card publication. Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS

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GUT-ASSOCIATED PLASMACYTOID DENDRITIC CELLS DISPLAY AN IMMATURE PHENOTYPE AND UPREGULATED GRANZYME B IN SUBJECTS WITH HIV/AIDS

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Lombardi Vinsent Klifford , author

Martynova Ekaterina Vladimirovna, author

Khaybullina Svetlana Francevna, author

Bibliographic description in the original language

Boichuk S.V. Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS / S.V. Boichuk, S.F. Khaiboullina, B.R. Ramazanov, G.R. Khasanova, K.A. Ivanovskaya, E.Z. Nizamutdinov, M.R. Sharafutdinov, E.M. Martynova, K.L. DeMeirleir, J. Hulstaert, V.A. Anokhin, A.A. Rizvanov, V.C. Lombardi // Frontiers in Immunology. – 2015. – Vol.6. – Article 485.

Annotation

Plasmacytoid dendritic cells in the periphery of subjects with HIV/AIDS decrease over time and the fate of these cells has been the subject of ongoing investigation. Previous studies using animal models as well as studies with humans suggest that these cells may redistribute to the gut. Other studies using animal models propose that the periphery pDCs are depleted and gut is repopulated with naïve pDCs from the bone marrow. In the present study, we utilized immunohistochemistry to survey duodenum biopsies of subjects with HIV/AIDS and controls. We observed that subjects with HIV/AIDS had increased infiltration of Ki-67+/CD303+ pDCs, a phenotype consistent with bone marrow derived pre-pDCs. In contrast, Ki-67+/CD303+ pDCs were not observed in control biopsies. We additionally observed that gut-associated pDCs in HIV/AIDS cases upregulate the proapototic enzyme granzyme B; however, no granzyme B was observed in the pDCs of control biopsies.

Keywords

hiv/aids, plasmacytoid dendritic cell, pDc, gut, granzyme B

The name of the journal

Frontiers in Immunology

URL

http://journal.frontiersin.org/article/10.3389/fimmu.2015.00485/abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113234&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Martynova Ekaterina Vladimirovna	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Boichuk S.V. Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS / S.V. Boichuk, S.F. Khaiboullina, B.R. Ramazanov, G.R. Khasanova, K.A. Ivanovskaya, E.Z. Nizamutdinov, M.R. Sharafutdinov, E.�. Martynova, K.L. DeMeirleir, J. Hulstaert, V.A. Anokhin, A.A. Rizvanov, V.C. Lombardi // Frontiers in Immunology. – 2015. – Vol.6. – Article 485.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113234&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Immunology	ru_RU
dc.description.abstract	Plasmacytoid dendritic cells in the periphery of subjects with HIV/AIDS decrease over time and the fate of these cells has been the subject of ongoing investigation. Previous studies using animal models as well as studies with humans suggest that these cells may redistribute to the gut. Other studies using animal models propose that the periphery pDCs are depleted and gut is repopulated with naïve pDCs from the bone marrow. In the present study, we utilized immunohistochemistry to survey duodenum biopsies of subjects with HIV/AIDS and controls. We observed that subjects with HIV/AIDS had increased infiltration of Ki-67+/CD303+ pDCs, a phenotype consistent with bone marrow derived pre-pDCs. In contrast, Ki-67+/CD303+ pDCs were not observed in control biopsies. We additionally observed that gut-associated pDCs in HIV/AIDS cases upregulate the proapototic enzyme granzyme B; however, no granzyme B was observed in the pDCs of control biopsies.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hiv/aids	ru_RU
dc.subject	plasmacytoid dendritic cell	ru_RU
dc.subject	pDc	ru_RU
dc.subject	gut	ru_RU
dc.subject	granzyme B	ru_RU
dc.title	Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS	ru_RU
dc.type	Articles in international journals and collections	ru_RU