KFU. Card publication. Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome

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FEDERAL UNIVERSITY

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MULTIPLEX ANALYSIS OF SERUM CYTOKINES IN HUMANS WITH HANTAVIRUS PULMONARY SYNDROME

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Lombardi Vinsent Klifford , author

Khaybullina Svetlana Francevna, author

Bibliographic description in the original language

Morzunov S.P. Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome / S.P. Morzunov, S.F. Khaiboullina, S. St_Jeor, A.A. Rizvanov, V.C. Lombardi // Frontiers in Microbiology. – 2015. – Vol.6. – Article 00432.

Annotation

Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability without a visible cytopathic effect. For this reason, it has been suggested that the pathogenesis of HPS is indirect with immune responses, such as cytokine production, playing a dominant role. In order to investigate their potential contribution to HPS pathogenesis, we analyzed the serum of hantavirus-infected subjects and healthy controls for 68 different cytokines, chemokines, angiogenic, and growth factors. Our analysis identified differential expression of cytokines that promote tissue migration of mononuclear cells including T lymphocytes, natural killer cells, and dendritic cells.

Keywords

hantavirus pulmonary syndrome, serum, cytokines, chemokines, growth factors, immune response, hantaviruses

The name of the journal

Frontiers in Microbiology

URL

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553709/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113224&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Morzunov S.P. Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome / S.P. Morzunov, S.F. Khaiboullina, S. St_Jeor, A.A. Rizvanov, V.C. Lombardi // Frontiers in Microbiology. – 2015. – Vol.6. – Article 00432.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113224&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Microbiology	ru_RU
dc.description.abstract	Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability without a visible cytopathic effect. For this reason, it has been suggested that the pathogenesis of HPS is indirect with immune responses, such as cytokine production, playing a dominant role. In order to investigate their potential contribution to HPS pathogenesis, we analyzed the serum of hantavirus-infected subjects and healthy controls for 68 different cytokines, chemokines, angiogenic, and growth factors. Our analysis identified differential expression of cytokines that promote tissue migration of mononuclear cells including T lymphocytes, natural killer cells, and dendritic cells.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hantavirus pulmonary syndrome	ru_RU
dc.subject	serum	ru_RU
dc.subject	cytokines	ru_RU
dc.subject	chemokines	ru_RU
dc.subject	growth factors	ru_RU
dc.subject	immune response	ru_RU
dc.subject	hantaviruses	ru_RU
dc.title	Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome	ru_RU
dc.type	Articles in international journals and collections	ru_RU