KFU. Card publication. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis

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CCL27: NOVEL CYTOKINE WITH POTENTIAL ROLE IN PATHOGENESIS OF MULTIPLE SCLEROSIS

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Beluchi Saverio , author

Lombardi Vinsent Klifford , author

Martynova Ekaterina Vladimirovna, author

Khaybullina Svetlana Francevna, author

Bibliographic description in the original language

Khaiboullina S.F. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis / S.F. Khaiboullina, A.R. Gumerova, I.Khafizova, E.V. Martynova, V.C. Lombardi, S. Bellusci, A.A. Rizvanov // BioMed Research International. - Vol. 2015. - 2015. - Article ID 189638. - DOI: 10.1155/2015/189638.

Annotation

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis.

Keywords

Multiple sclerosis, CCL27

The name of the journal

BioMed Research International

URL

http://www.hindawi.com/journals/bmri/2015/189638/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113218&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Beluchi Saverio	ru_RU
dc.contributor.author	Lombardi Vinsent Klifford	ru_RU
dc.contributor.author	Martynova Ekaterina Vladimirovna	ru_RU
dc.contributor.author	Khaybullina Svetlana Francevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Khaiboullina S.F. CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis / S.F. Khaiboullina, A.R. Gumerova, I.Khafizova, E.V. Martynova, V.C. Lombardi, S. Bellusci, A.A. Rizvanov // BioMed Research International. - Vol. 2015. - 2015. - Article ID 189638. - DOI: 10.1155/2015/189638.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113218&p_lang=2	ru_RU
dc.description.abstract	BioMed Research International	ru_RU
dc.description.abstract	Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain tissue and the subsequent inflammation, demyelination, axonal damage, and formation of sclerotic plaques is a hallmark of MS. Upregulation of proinflammatory cytokines has been suggested to play an essential role in regulating lymphocyte migration in MS. Here we present data on serum cytokine expression in MS cases. Increased serum levels of IL-17 and IL-23 were observed, suggesting activation of the Th17 population of immune effector cells. Additionally, increased levels of IL-22 were observed in the serum of those with acute phase MS. Unexpectedly, we observed an upregulation of the serum chemokine CCL27 in newly diagnosed and acute MS cases. CCL27 is an inflammatory chemokine associated with homing of memory T cells to sites of inflammation. Therefore, its upregulation in association with MS suggests a potential role in disease pathogenesis.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Multiple sclerosis	ru_RU
dc.subject	CCL27	ru_RU
dc.title	CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis	ru_RU
dc.type	Articles in international journals and collections	ru_RU