Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
HUMAN ADIPOSE-DERIVED STEM CELLS STIMULATE NEUROREGENERATION
Form of presentationArticles in international journals and collections
Year of publication2015
Языканглийский
  • Doktor Palotash Andrash Levente , author
  • Zhuravleva Margarita Nikolaevna, author
  • Kiyasov Andrey Pavlovich, author
  • Masgutov Ruslan Faridovich, author
  • Masgutova Galina Andreevna, author
  • Mukhamedshina Yana Olegovna, author
  • Mukhametshina Regina Talgatovna, author
  • Salafutdinov Ilnur Ildusovich, author
  • Bibliographic description in the original language Masgutov R.F. Human adipose-derived stem cells stimulate neuroregeneration / R.F. Masgutov, G.A. Masgutova, M.N. Zhuravleva, I.I. Salafutdinov, R.T. Mukhametshina, Y.O. Mukhamedshina, L.M. Lima, H.J. Reis, A.P. Kiyasov, A. Palotás, A.A. Rizvanov // Clinical and Experimental Medicine - 2015. - PubMed PMID: 26047869. DOI: 10.1007/s10238-015-0364-3.
    Annotation Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis and many others are characterized by loss of brain cells and supporting structures. Restoring microanatomy and function using stem cells is a promising therapeutic approach. Among the many various sources, adipose-derived stem cells (ADSCs) are one of the most easily harvested alternatives, they multiply rapidly, and they demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective of this study was to evaluate the effect of xenotransplanted human ADSCs on post-traumatic regeneration of rat sciatic nerve. Peripheral reconstruction following complete sciatic transection and autonerve grafting was complemented by intra-operative injection of hADSCs into the proximal and distal stumps.
    Keywords Autonerve graft Human adipose-derived stem cell (hADSC), Xenotransplantation, Peripheral nerve injury, Regenerative medicine, Repair
    The name of the journal Clinical and Experimental Medicine
    URL http://www.ncbi.nlm.nih.gov/pubmed/26047869
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=113206&p_lang=2

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