KFU. Card publication. Human adipose-derived stem cells stimulate neuroregeneration

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

HUMAN ADIPOSE-DERIVED STEM CELLS STIMULATE NEUROREGENERATION

Form of presentation

Articles in international journals and collections

Year of publication

2015

Язык

английский

Authors, employees of KFU

Doktor Palotash Andrash Levente , author

Zhuravleva Margarita Nikolaevna, author

Kiyasov Andrey Pavlovich, author

Masgutov Ruslan Faridovich, author

Masgutova Galina Andreevna, author

Mukhamedshina Yana Olegovna, author

Mukhametshina Regina Talgatovna, author

Salafutdinov Ilnur Ildusovich, author

Bibliographic description in the original language

Masgutov R.F. Human adipose-derived stem cells stimulate neuroregeneration / R.F. Masgutov, G.A. Masgutova, M.N. Zhuravleva, I.I. Salafutdinov, R.T. Mukhametshina, Y.O. Mukhamedshina, L.M. Lima, H.J. Reis, A.P. Kiyasov, A. Palotás, A.A. Rizvanov // Clinical and Experimental Medicine - 2015. - PubMed PMID: 26047869. DOI: 10.1007/s10238-015-0364-3.

Annotation

Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis and many others are characterized by loss of brain cells and supporting structures. Restoring microanatomy and function using stem cells is a promising therapeutic approach. Among the many various sources, adipose-derived stem cells (ADSCs) are one of the most easily harvested alternatives, they multiply rapidly, and they demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective of this study was to evaluate the effect of xenotransplanted human ADSCs on post-traumatic regeneration of rat sciatic nerve. Peripheral reconstruction following complete sciatic transection and autonerve grafting was complemented by intra-operative injection of hADSCs into the proximal and distal stumps.

Keywords

Autonerve graft Human adipose-derived stem cell (hADSC), Xenotransplantation, Peripheral nerve injury, Regenerative medicine, Repair

The name of the journal

Clinical and Experimental Medicine

URL

http://www.ncbi.nlm.nih.gov/pubmed/26047869

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113206&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Doktor Palotash Andrash Levente	ru_RU
dc.contributor.author	Zhuravleva Margarita Nikolaevna	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Masgutov Ruslan Faridovich	ru_RU
dc.contributor.author	Masgutova Galina Andreevna	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Mukhametshina Regina Talgatovna	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Masgutov R.F. Human adipose-derived stem cells stimulate neuroregeneration / R.F. Masgutov, G.A. Masgutova, M.N. Zhuravleva, I.I. Salafutdinov, R.T. Mukhametshina, Y.O. Mukhamedshina, L.M. Lima, H.J. Reis, A.P. Kiyasov, A. Palotás, A.A. Rizvanov // Clinical and Experimental Medicine - 2015. - PubMed PMID: 26047869. DOI: 10.1007/s10238-015-0364-3.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113206&p_lang=2	ru_RU
dc.description.abstract	Clinical and Experimental Medicine	ru_RU
dc.description.abstract	Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis and many others are characterized by loss of brain cells and supporting structures. Restoring microanatomy and function using stem cells is a promising therapeutic approach. Among the many various sources, adipose-derived stem cells (ADSCs) are one of the most easily harvested alternatives, they multiply rapidly, and they demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective of this study was to evaluate the effect of xenotransplanted human ADSCs on post-traumatic regeneration of rat sciatic nerve. Peripheral reconstruction following complete sciatic transection and autonerve grafting was complemented by intra-operative injection of hADSCs into the proximal and distal stumps.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Autonerve graft Human adipose-derived stem cell (hADSC)	ru_RU
dc.subject	Xenotransplantation	ru_RU
dc.subject	Peripheral nerve injury	ru_RU
dc.subject	Regenerative medicine	ru_RU
dc.subject	Repair	ru_RU
dc.title	Human adipose-derived stem cells stimulate neuroregeneration	ru_RU
dc.type	Articles in international journals and collections	ru_RU