KFU. Card publication. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair

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FEDERAL UNIVERSITY

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ATTENUATING ENDOGENOUS FGFR2B LIGANDS DURING BLEOMYCIN-INDUCED LUNG FIBROSIS DOES NOT COMPROMISE MURINE LUNG REPAIR

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Beluchi Saverio , author

Bibliographic description in the original language

MacKenzie B. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair / B. MacKenzie, I. Henneke, S. Hezel, D. Al Alam, E. El Agha, C.M. Chao, J. Quantius, J. Wilhelm, M. Jones, K. Goth, X. Li, W. Seeger, M. Königshoff, S. Herold, A.A. Rizvanov, A. Günther, S. Bellusci // American Journal of Physiology. - Lung Cellular and Molecular Physiology. – 2015. – Vol.308 (10). – P.L1014-L1024.

Annotation

Fibroblast growth factors (Fgfs) mediate organ repair. Lung epithelial cell overexpression of Fgf10 postbleomycin injury is both protective and therapeutic, characterized by increased survival and attenuated fibrosis. Exogenous administration of FGF7 (palifermin) also showed prophylactic survival benefits in mice. The role of endogenous Fgfr2b ligands on bleomycin-induced lung fibrosis is still elusive. This study reports the expression of endogenous Fgfr2b ligands, receptors, and signaling targets in wild-type mice following bleomycin lung injury. In addition, the impact of attenuating endogenous Fgfr2b-ligands following bleomycin-induced fibrosis was tested by using a doxycycline (dox)-based inducible, soluble, dominant-negative form of the Fgfr2b receptor. Double-transgenic (DTG) Rosa26(rtTA/+);tet(O)solFgfr2b mice were validated for the expression and activity of soluble Fgfr2b (failure to regenerate maxillary incisors, attenuated recombinant FGF7 signal in the lung).

Keywords

Fibroblast growth factors, Lung epithelial cell

The name of the journal

Am J Physiol Lung Cell Mol Physiol

URL

http://www.ncbi.nlm.nih.gov/pubmed/25820524

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113202&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Beluchi Saverio	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	MacKenzie B. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair / B. MacKenzie, I. Henneke, S. Hezel, D. Al Alam, E. El Agha, C.M. Chao, J. Quantius, J. Wilhelm, M. Jones, K. Goth, X. Li, W. Seeger, M. Königshoff, S. Herold, A.A. Rizvanov, A. Günther, S. Bellusci // American Journal of Physiology. - Lung Cellular and Molecular Physiology. – 2015. – Vol.308 (10). – P.L1014-L1024.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113202&p_lang=2	ru_RU
dc.description.abstract	Am J Physiol Lung Cell Mol Physiol	ru_RU
dc.description.abstract	Fibroblast growth factors (Fgfs) mediate organ repair. Lung epithelial cell overexpression of Fgf10 postbleomycin injury is both protective and therapeutic, characterized by increased survival and attenuated fibrosis. Exogenous administration of FGF7 (palifermin) also showed prophylactic survival benefits in mice. The role of endogenous Fgfr2b ligands on bleomycin-induced lung fibrosis is still elusive. This study reports the expression of endogenous Fgfr2b ligands, receptors, and signaling targets in wild-type mice following bleomycin lung injury. In addition, the impact of attenuating endogenous Fgfr2b-ligands following bleomycin-induced fibrosis was tested by using a doxycycline (dox)-based inducible, soluble, dominant-negative form of the Fgfr2b receptor. Double-transgenic (DTG) Rosa26(rtTA/+);tet(O)solFgfr2b mice were validated for the expression and activity of soluble Fgfr2b (failure to regenerate maxillary incisors, attenuated recombinant FGF7 signal in the lung).	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Fibroblast growth factors	ru_RU
dc.subject	Lung epithelial cell	ru_RU
dc.title	Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair	ru_RU
dc.type	Articles in international journals and collections	ru_RU