KFU. Card publication. Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels

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FEDERAL UNIVERSITY

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OXIDATIVE STRESS AND MAXI CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS

Form of presentation

Articles in international journals and collections

Year of publication

2015

Язык

английский

Authors, employees of KFU

Sitdikova Guzel Faritovna, author

Other authors

Hermann Anton A, author

Bibliographic description in the original language

Anton Hermann 1,*, Guzel F. Sitdikova 2 and Thomas M. Weiger Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels// Biomolecules 2015, 5, 1-x manuscripts; doi:10.3390/biom50x000x

Annotation

All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.

Keywords

Maxi calcium-activated potassium ion channels; BK channels; KCNMA1; redox mechanisms; oxidation; hypoxia; ischemia

The name of the journal

Biomolecules

URL

http://www.mdpi.com/search?q=&journal=biomolecules&volume=&authors=Hermann§ion=&issue=&article_type=&special_issue=&page=&search=Search

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=112261&p_lang=2

Resource files

File name	Size (MB)	Format
biomolecules_86563_final.pdf	0,58	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Hermann Anton A	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Anton Hermann 1,*, Guzel F. Sitdikova 2 and Thomas M. Weiger Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels// Biomolecules 2015, 5, 1-x manuscripts; doi:10.3390/biom50x000x	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=112261&p_lang=2	ru_RU
dc.description.abstract	Biomolecules	ru_RU
dc.description.abstract	All cells contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK) channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels	ru_RU
dc.type	Articles in international journals and collections	ru_RU