KFU. Card publication. echanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction

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FEDERAL UNIVERSITY

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ECHANISMS OF HYDROGEN SULFIDE (H2S) ACTION ON SYNAPTIC TRANSMISSION AT THE MOUSE NEUROMUSCULAR JUNCTION

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Gerasimova Elena Vyacheslavovna, author

Giniatullin Rashid Askhatovich, author

Sitdikova Guzel Faritovna, author

Yakovlev Aleksey Valerevich, author

Bibliographic description in the original language

Gerasimova E. Mechanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction / Gerasimova E., Lebedeva J., Yakovlev A., Zefirov A., Giniatullin R., Sitdikova G. // Neuroscience. - 2015

Annotation

Hydrogen sulfide (H2S) is a widespread gasotransmitter known also as a powerful neuroprotective agent in the central nervous system. However, the action of H2S in peripheral synapses is much less studied. In the current project we studied the modulatory effects of the H2S donor sodium hydrogen sulfide (NaHS) on synaptic transmission in the mouse neuromuscular junction using microelectrode technique. Using focal recordings of presynaptic response and evoked transmitter release we have shown that NaHS (300 μM) increased evoked endplate currents (EPCs) without changes of presynaptic waveforms which indicated the absence of NaHS effects on sodium and potassium currents of motor nerve endings. Using intracellular recordings it was shown that NaHS increased the frequency of miniature endplate potentials (MEPPs) without changing their amplitudes indicating a pure presynaptic effect. Furthermore, NaHS increased the amplitude of endplate potentials (EPPs) without influence on the resting membra

Keywords

Hydrogen sulfide; Neuromuscular junction; Transmitter release; L-cysteine; Adenylate cyclase; Ryanodine receptors

The name of the journal

NEUROSCIENCE

URL

http://www.sciencedirect.com/science/article/pii/S0306452215006508

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=111118&p_lang=2

Resource files

File name	Size (MB)	Format
1_s2.0_S0306452215006508_main.pdf	0,29	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimova Elena Vyacheslavovna	ru_RU
dc.contributor.author	Giniatullin Rashid Askhatovich	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Yakovlev Aleksey Valerevich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Gerasimova E. Mechanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction / Gerasimova E., Lebedeva J., Yakovlev A., Zefirov A., Giniatullin R., Sitdikova G. // Neuroscience. - 2015	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=111118&p_lang=2	ru_RU
dc.description.abstract	NEUROSCIENCE	ru_RU
dc.description.abstract	Hydrogen sulfide (H2S) is a widespread gasotransmitter known also as a powerful neuroprotective agent in the central nervous system. However, the action of H2S in peripheral synapses is much less studied. In the current project we studied the modulatory effects of the H2S donor sodium hydrogen sulfide (NaHS) on synaptic transmission in the mouse neuromuscular junction using microelectrode technique. Using focal recordings of presynaptic response and evoked transmitter release we have shown that NaHS (300 μM) increased evoked endplate currents (EPCs) without changes of presynaptic waveforms which indicated the absence of NaHS effects on sodium and potassium currents of motor nerve endings. Using intracellular recordings it was shown that NaHS increased the frequency of miniature endplate potentials (MEPPs) without changing their amplitudes indicating a pure presynaptic effect. Furthermore, NaHS increased the amplitude of endplate potentials (EPPs) without influence on the resting membra	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	echanisms of Hydrogen Sulfide (H2S) Action on Synaptic Transmission at the Mouse Neuromuscular Junction	ru_RU
dc.type	Articles in international journals and collections	ru_RU