KFU. Card publication. Anti-inflammatory and anti-mutagenic effect of the YHK phytocompound in hepatocytes: In view of an age-management liver-protecting approach

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ANTI-INFLAMMATORY AND ANTI-MUTAGENIC EFFECT OF THE YHK PHYTOCOMPOUND IN HEPATOCYTES: IN VIEW OF AN AGE-MANAGEMENT LIVER-PROTECTING APPROACH

Form of presentation

Articles in international journals and collections

Year of publication

2014

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Authors, employees of KFU

Trushin Maksim Viktorovich, author

Bibliographic description in the original language

Catanzaro, R., Celep, G., Illuzzi, N., Milazzo, M.a, Rastmanesh, R., Yaduvanshi, S.K., He, F., Trushin, M., Sapienza, C., Srivastava, N., Marotta, F. Anti-inflammatory and anti-mutagenic effect of the YHK phytocompound in hepatocytes: In view of an age-management liver-protecting approach // Rejuvenation Research Volume 17, Issue 2, Pages 168-171.

Annotation

Rejuvenation Research

Keywords

antiinflammatory activity; article; cancer cell culture; cancer prevention; cell growth; cell proliferation; drug effect; gene expression; in vitro study; intervention study; liver cell; liver cell carcinoma; liver protection; mutagenic activity; priority journal

The name of the journal

Rejuvenation Research

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=108342&p_lang=2

Resource files

File name	Size (MB)	Format
paper_108_RR_YHK.pdf	0,34	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Trushin Maksim Viktorovich	ru_RU
dc.contributor.author	Trushin Maksim Viktorovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Catanzaro, R., Celep, G., Illuzzi, N., Milazzo, M.a, Rastmanesh, R., Yaduvanshi, S.K., He, F., Trushin, M., Sapienza, C., Srivastava, N., Marotta, F. Anti-inflammatory and anti-mutagenic effect of the YHK phytocompound in hepatocytes: In view of an age-management liver-protecting approach // Rejuvenation Research Volume 17, Issue 2, Pages 168-171.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=108342&p_lang=2	ru_RU
dc.description.abstract	Rejuvenation Research	ru_RU
dc.description.abstract	The receptor for advanced glycation end products (RAGE) regulates cellular proliferation in hepatocellular carcinoma (HCC). The aim of this study was to test the in vitro effect of Yo Jyo Hen Shi Ko (YHK), a nutraceutical with prior data suggesting its hepatocyte-protecting role, in regulating RAGE in the proliferation of the HCC cell line HuH7 as well checking also its potential modulation in the expression of the transcriptional factor nuclear factor-κB (NF-κB) p65. Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line (p<0.05). Moreover, this phytocompound partly reduced gene expression of NF-κB p65 (by 35%, p<0.05). These data suggest that YHK has a potential role as a modulator of RAGE and RAGE ligands for potential healthy liver intervention in HCC prevention strategies	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Anti-inflammatory and anti-mutagenic effect of the YHK phytocompound in hepatocytes: In view of an age-management liver-protecting approach	ru_RU
dc.type	Articles in international journals and collections	ru_RU