KFU. Card publication. Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations.

KAZAN
FEDERAL UNIVERSITY

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ELECTROCHEMICAL BIOSENSORS BASED ON NATIVE DNA AND NANOSIZED MEDIATOR FOR THE DETECTION OF ANTHRACYCLINE PREPARATIONS.

Form of presentation

Articles in international journals and collections

Year of publication

2015

Authors, employees of KFU

Budnikov German Konstantinovich, author

Evtyugin Gennadiy Arturovich, author

Porfireva Anna Veniaminovna, author

Stepanova Veronika Borisovna, author

Bibliographic description in the original language

Evtugyn, G. Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations [Text] / G.Evtugyn, A.Porfireva, V.Stepanova, H.Budnikov // Electroanalysis- 2015.- V.27, N2.- P.629-637.

Annotation

A novel electrochemical DNA-sensor based on glassy carbon electrode (GCE) modified with electropolymerized Neutral red (NR) and polycarboxylated thiacax[4]arene with covalently attached mediator and electrostatically adsorbed DNA was developed for sensitive detection of anthracycline preparations. Intercalation of doxorubicin, daunorubicin and idarubicin into DNA increases the charge transfer resistance and decreases the electron exchange resulted in decay of the cathodic peak of NR reduction. The DNA-sensor developed makes it possible to determine down to 0.05 nM doxorubicin, o.1 nM doxorubicin and 0.5 nM idarubicin. The DNA-sensor was tested on detection of doxorubicin in pharmaceuticals and artificial blood plasma with 95?100 % recovery.

Keywords

DNA sensor, Anthracycline pharmaceuticals, Poly(Neutral red), Nanosized mediator, Electrochemical impedance

The name of the journal

ELECTROANAL

URL

http://onlinelibrary.wiley.com/doi/10.1002/elan.201400564/abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=104406&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Budnikov German Konstantinovich	ru_RU
dc.contributor.author	Evtyugin Gennadiy Arturovich	ru_RU
dc.contributor.author	Porfireva Anna Veniaminovna	ru_RU
dc.contributor.author	Stepanova Veronika Borisovna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Evtugyn, G. Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations [Text] / G.Evtugyn, A.Porfireva, V.Stepanova, H.Budnikov // Electroanalysis- 2015.- V.27, N2.- P.629-637.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=104406&p_lang=2	ru_RU
dc.description.abstract	ELECTROANAL	ru_RU
dc.description.abstract	A novel electrochemical DNA-sensor based on glassy carbon electrode (GCE) modified with electropolymerized Neutral red (NR) and polycarboxylated thiacax[4]arene with covalently attached mediator and electrostatically adsorbed DNA was developed for sensitive detection of anthracycline preparations. Intercalation of doxorubicin, daunorubicin and idarubicin into DNA increases the charge transfer resistance and decreases the electron exchange resulted in decay of the cathodic peak of NR reduction. The DNA-sensor developed makes it possible to determine down to 0.05 nM doxorubicin, o.1 nM doxorubicin and 0.5 nM idarubicin. The DNA-sensor was tested on detection of doxorubicin in pharmaceuticals and artificial blood plasma with 95?100 % recovery.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	DNA sensor	ru_RU
dc.subject	Anthracycline pharmaceuticals	ru_RU
dc.subject	Poly(Neutral red)	ru_RU
dc.subject	Nanosized mediator	ru_RU
dc.subject	Electrochemical impedance	ru_RU
dc.title	Electrochemical biosensors based on native DNA and nanosized mediator for the detection of anthracycline preparations.	ru_RU
dc.type	Articles in international journals and collections	ru_RU