KAZAN
FEDERAL UNIVERSITY
Kiseleva Anna Alekseevna (архив)
Research work
03.03.04 - Клеточная биология, цитология, гистология
Performance
Quantity of published work in Scopus:
2
Quantity of reference on published work in Scopus:
2
Personal index of Hirsh:
2
Performance
2020
Kiseleva A.A. Informatics-guided drug repurposing for Autosomal Dominant Polycystic Kidney Disease (ADPKD) / A.A. Kiseleva, E.A. Golemis // EBioMedicine. - 2020 Jan 22; 52: 102628. doi: 10.1016/j.ebiom.2020.102628.
F_PIIS2352396420300037.pdf
2019
Kiseleva Anna Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs / A. Kiseleva, V. Korobeynikov, A. Nikonova, P. Zhang, P. Makhov, A. Deneka, M. Einarson, I. Serebriiskii, H. Liu, J. Peterson, E. Golemis // Clinical Cancer Research. - 2019. - Vol. 25(13). - P. 4179-4193.
Zhang, P. Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation / P. Zhang, A.A. Kiseleva, V. Korobeynikov, H. Liu, M.B. Einarson, E.A. Golemis // Frontiers in genetics. - 2019. - Vol. 10. - Article 75. doi10.3389/fgene.2019.00075.
2018
Liu H, Kiseleva A.A, Golemis E.A., Ciliary signalling in cancer//Nature Reviews Cancer. - 2018. - Vol., Is.. - P.1-14.
Kiseleva Anna Chapter 2. Targeting the ErbB Family in Head and Neck Cancer / A.A. Kiseleva, T.N. Beck, I.G. Serebriiskii, H. Liu, B. Burtness, E. Golemis // Current Cancer Research. - Springer Nature, Switzerland, 2018. - 55 p.
2017
The primary cilium is an antenna-like structure protruding from the cell surface, which provides a platform for receptors for signaling systems including PDGF-alpha, Hedgehog, Wnt, and others that influence cell differentiation and proliferation decisions. Under normal physiological growth conditions, the cilium forms after mitosis and in quiescent cells, extending from a basal body centered at a centriole, with timed resorption in G0 or early G1. Cancer cells have altered ciliary dynamics, with some (medulloblastomas and basal cell carcinomas) often dependent on cilia, and other tumor types downregulating them. In prior work, we defıned Aurora-A, an oncogenic kinase typically thought of as a mitotic regulator, as transiently activated at the basal body, and absolutely required for resorption of cilia at the G0/G1 boundary, and we showed the targeted Aurora-A inhibitor entirely blocked ciliary resorption. In subsequent work, we found that a second drug, the EGFR inhibitor erlotinib, al
2016
Varvara K.K, Anna A.K, Ryan J.I, Combination of eribulin and aurora a inhibitor MLN8237 prevents metastatic colonization and induces cytotoxic autophagy in breast cancer//Molecular Cancer Therapeutics. - 2016. - Vol.15, Is.8. - P.1809-1822.
Work address:
18 Kremlevskaya Str., Kazan, Building #02 (Eastern wing of the University's main building)
Office number:
104B
Phone:
2337842
E-mail:
AnnAKiseleva@kpfu.ru
Google scholar:
https://scholar.google.com/citations?user=EX8kaeoAAAAJ&hl=en