Date of birth
20.11.1982
Positions
Performance
Performance
2023
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Shtyrlin N.V, Kayumov A.R, Agafonova M.N, Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety//European Journal of Medicinal Chemistry. - 2023. - Vol.261, Is.. - Art. №115798.
1_s2.0_S0223523423007651.pdf -
Zakirova E., Aimaletdinov A. , Mansurova M., Titova A., Kurilov I., Rutland C., Malanyeva A., Rizvanov A. Artificial Microvesicles: New Perspective on Healing Tendon Wounds. Cells Tissues Organs 2022. https://doi.org/10.1159/000526845
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Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G. et al. Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal / Aleksandrova, N.M., Aimaletdinov, A.M., Malanyeva, A.G., Rizvanov A.A., Zakirova E.Yu. // Stem Cells. Appl Biochem Microbiol. - 2023. - №59. - р. 1071–1077.
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Tambovsky, M.A.Current Trends in the Application of Stem Cells and Their Derivatives in Animal Sperm Cryopreservation / Tambovsky, M.A., Aimaletdinov, A.M. & Zakirova, E.Y. // Biochem. Moscow Suppl. Ser. A. - 2023. - №17. - р.243–248.
BioChMsA2305011TambovskiiKOR.pdf -
.V. Bondar, R. Karwt, T. Mohammad, R.S. Pavelyev, M.V. Pugachev, Be.B. Ygaiev, A.R. Kayumov, A.M. Aimaletdinov, and Y.G. Shtyrlin. Structural Analogs of Dehydrozingerone Containing a Pyridoxine Fragment Exhibit Membrane-Modulating Properties and Synergistically Enhance the Antitumor Activity of Cytostatics // Russian Journal of Bioorganic Chemistry, 2023, 49 (4), P. 797-814. ISSN 1068-1620. DOI: 10.1134/S106816202304009X
F_Finalnaya_versiya_stati_s_nomerami_stranic.pdf
2022
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Zakirova E. Handbook of Stem Cell Therapy / E. Zakirova, A. M. Aimaletdinov, A. G. Malanyeva, С. S. Rutland, and A. A. Rizvanov; K. H. Haider (ed.). - Springer Nature Singapore Pte Ltd, 2022.
F_Zakirova2022_ReferenceWorkEntry_PreclinicalResearchOfMesenchym.pdf -
Aimaletdinov A. М. Isolation, culturing and 3D bioprinting equine myoblasts / А.М.Aimaletdinov, М. Abyzova, I. Kurilov, A. Yuferova, C. Rutland, A.A. Rizvanov, E.Yu. Zakirova // Biological Communications. - 2022. - № 67(3). - р.152–159.
F_12821_Article_Text_47902_1_10_20221009.pdf -
Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency of β-hexosaminidase A (HexA) enzyme, which results in the accumulation of GM2 gangliosides in the nervous system cells. In this work, we analyzed the efficacy and safety of cell-mediated gene therapy for Sandhoff disease and Sandhoff disease using a bicistronic lentiviral vector encoding cDNA of HexA α- and β-subunit genes separated by the nucleotide sequence of a P2A peptide (HEXA-HEXB). The functionality of the bicistronic construct containing the HEXA-HEXB genetic cassette was analyzed in a culture of HEK293T cells and human umbilical cord blood mononuclear cells (hUCBMCs). Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB and hUCBMCs-HEXA-HEXB was increased by 23 and 8 times, respectively, compared with the conditioned medium of native cells. Western blot analysis showed that hUCBMCs-HEXA
NRR_17_122.pdf
2021
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Ganiev, I., Alexandrova, N., Aimaletdinov, A., Rutland, C., Malanyeva, A.,
Rizvanov, A and Zakirova E. 2021. The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species. Open Vet. J. 11(1), 128-134.
OVJ_2020_08_264_I._Ganiev_et_al.pdf -
Efimova M., Zakirova E., Kuzmin V., Aimaletdinov A., Garipov L., Khaertynov K., Davidyuk Y., Shuralev E., Rizvanov A., Ravilov R. Analysis and selection of genes encoding the expression of protective antigens of the African swine fever virus for further development of a vaccine based on adeno-associated virus vector // Proceeding of the 69th WDA /14th EWDA 2021 Joint Conference (Cuenca, Spain, 31.08.2021 – 02.09.2021).– Cuenca, 2021. – P. 361.
F_ASF_Abstract.pdf -
Efimova M, Zakirova E, Kuzmin V, Aimaletdinov A, Garipov L, Khaertynov K, Davidyuk Y, Shuralev E, Rizvanov A, Ravilov R. Analysis and selection of genes encoding the expression of protective antigens of the African swine fever virus for further development of a vaccine based on adeno-associated virus vector (poster presentation) // 69th WDA /14th EWDA 2021 Joint Conference. – Cuenca, Spain. – 31.08.2021 – 02.09.2021. – Online: https://www.cuenca2020.com
Shuralev_ASF_Poster.pdf
2020
- Патент США US10688084 от 23.06. 2020, дата приоритета 02.11.2016. Method of use of novel naproxen derivatives/ Shtyrlin Yurij G.; Pavel'ev Roman S.; Iksanova Al'fiya G.; Shtyrlin Nikita V.; Pugachev Mikhail V.; Balakin Konstantin V.; Ajmaletdinov Aleksandr M.; Ganiev Il'nur M.; Malan'eva Al'bina G.
- Патент Евразийского союза EA034652 от 03.03. 2020, дата приоритета 02.11.2016. Нестероидное противовоспалительное средство на основе напроксена, обладающее низкой гастротоксичностью / Ю.Г. Штырлин, Р.С. Павельев, А.Г. Иксанова, Н.В. Штырлин, М.В. Пугачев, К.В. Балакин, А.М. Аймалетдинов, И.М. Ганиев, А.Г. Маланьева.
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Aimaletdinov, A., Mindubaeva, G., Khalikova, S., Kabwe, E., Salmakova, A., Alexandrova, N., Rutland, C., Rizvanov, A. and Zakirova, E. 2020. Application of gene therapy in the treatment of superficial digital flexor tendon injury in horses. Open Vet. J. 10(3), 261-266.
OVJ_2020_02_048_A._Aimaletdinov_et_al_2.pdf -
Gomzikova M.O, Aimaletdinov A.M, Bondar O.V, Immunosuppressive properties of cytochalasin B-induced membrane vesicles of mesenchymal stem cells: comparing with extracellular vesicles derived from mesenchymal stem cells//Scientific Reports. - 2020. - Vol.10, Is.1. - Art. № 10740.
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Zakirova EY, Aimaletdinov AM, Malanyeva AG, Rutland CS and Rizvanov AA (2020) Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine. Front. Vet. Sci. 7:594044. doi: 10.3389/fvets.2020.594044
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Kurbangaleeva S. Microvesicles of mesenchymal stem cells demonstrate immunosuppressive activity in vivo / S. Kurbangaleeva, O. Neustroeva, A. Aimaletdinov, A. Rizvanov, M. Gomzikova // EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. – 2020. – Vol. 50. – P. 85-86.
F_Tezis_4._ESCI.pdf -
Закирова Е.Ю., Аймалетдинов А.М., Ганиев И.М., Ризванов А.А. Генная терапия в ветеринарной медицине // Материалы научно-практической конференции с международным участием «Генетика, селекция и биотехнология животных: на пути к совершенству« 13 - 15 октября 2020 года. - Пушкин: ВНИИГРЖ, 2020. - с. 120 - 121.
TEZIS_1_Ilnur.pdf - Zakirova E. Yu, Aimaletdinov A. M., Alexandrova N. M., Developing a Species-Specific Genetic Agent for Treatment of Skin Defects in Dogs//UCHENYE ZAPISKI KAZANSKOGO UNIVERSITETA-SERIYA ESTESTVENNYE NAUKI. - 2020. - Vol.162, Is.3. - P.361-380.
- Патент Европейского союза EP 3517525. «Naproxen-based non-steroidal anti-inflammatory drug with low gastric toxicity». Дата подачи заявки: 31.10.2017; Опубликовано: 19.08.2020. (Валидирован в Германии, Франции, Великобритании, Швейцарии, Ирландии и др.);
- Патент Японии JP 6757858. «Naproxen-based non-steroidal anti-inflammatory drug with low gastric toxicity». Дата подачи заявки: 31.10.2017; Опубликовано: 23.09.2020
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Закирова Е.Ю., Аймалетдинов А.М., Ганиев И.М., Ризванов А.А. Разработка методов получения больших объемов мышечной ткани // Материалы научно-практической конференции с международным участием «Генетика, селекция и биотехнология животных: на пути к совершенству« 13 - 15 октября 2020 года. - Пушкин: ВНИИГРЖ, 2020. - с. 118 - 119.
F_TEZIS_2_Ilnur.pdf
2019
2018
2017
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Garipov M.R. Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms / M.R. Garipov, R.S. Pavelyev, S.A. Lisovskaya, E.V. Nikitina, A.R. Kayumov, A.E. Sabirova, O.V. Bondar, A.G. Malanyeva, A.M. Aimaletdinov, A.G. Iksanova, K.V. Balakin, Y.G. Shtyrlin // Journal of Chemistry. - 2017. - Art. №4761650.
- Лицензионный договор № 2926161017 от 16 октября 2017 г. о предоставлении исключительной лицензии на использование изобретения «Нестероидное противовоспалительное средство на основе напроксена, обладающее низкой гастротоксичностью» по патенту РФ № 2629367.
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Bondar O. Mechanisms of Anticancer Activity of Novel Pyridoxine-based Bioisosteric Analogs of Dehydrozingerone. O Bondar R Pavelyev, T Nguyen, M Pugachev, G Alekbaeva, A Aimaletdinov, O Vasileva, A Lyubina, K Balakin, Y Shtyrlin // MOLECULAR BIOLOGY OF THE CELL.- 2017.- V28
F_2017ASCB_EMBOMeeting_PosterAbstractsfinal.pdf
| Work address: | 9 Parizhskoy Kommuny Str., Kazan, Academic and Research Centre of the Institute of Fundamental Medicine and Biology |
| Office number: | 205 |
| E-mail: | AMAjmaletdinov@kpfu.ru |
| Scientific and pedagogical experience: |
| General experience: |
| Experience in KFU: |