Article: Revisiting the Cytotoxicity of Cationic Polyelectrolytes as a Principal Component in Layer-by-Layer Assembly Fabrication

Authors: Ekaterina Naumenko, Farida Akhatova, Elvira Rozhina, Rawil Fakhrullin

Journal: Pharmaceutics, 2021, V. 13(8), P. 1230

Our research team has studied the influence of various water-soluble, positively charged synthetic polyelectrolytes on in vitro cytotoxicity, cell and nucleus morphology, and monolayer expansion changes. As a result, the most popular polyelectrolytes were ranked from the safest to the most toxic concerning cell cultures. The authors also noted that there exists a relationship between the structure of the polyelectrolytes and their toxicity, which is necessary for the optimization of drug and gene delivery systems.