Study of the principles of the brain functions and development, studying pathophysiological mechanisms underlying the major diseases of the central nervous system (epilepsy, brain ischemia, trauma, pain) to ameliorate diagnostics and to find cure against these diseases. Research interests: Neuronal network mechanisms underlying generation of the early patterns of electrical activity in the developing brain and their role in the formation of synaptic circuits. Pathophysiology of Epilepsy, Brain ischemia, Trauma, Pain. Neurobiology Lab is a partner of the International Associated Laboratory between KFU and INSERM, France.
Research of molecular mechanisms of action of natural and synthetic compounds with neurotropic activity to investigate the development of effective medical tools for treatment of diseases of central and peripheral nervous systems (Alzheimer's disease, myasthenic syndromes etc.) as well as cardiovascular pathologies and diabetes.
Application of combinatorial chemistry and biology for design of novel DNA-encoded scavengers for organophosphorus compounds capturing. Elaboration of “virtual maturation” of selected catalytic Ig repertoires with quantum mechanics/molecular mechanics (QM/MM) approach. Studying of molecular mechanisms of autoantigens' degradation and presentation in neurodegenerative diseases, particularly dealing with ubiquitin-independent degradation of myelin basic protein by constitutive and immune 26S proteasomes.
The aim of the project is the organization of international laboratory together with Institute of Materials for Electronics and Magnetism. Areas of the scientific activities of the laboratory: development of electronic devices mimicking properties of nervous system elements; realization of neuromorphic networks, based on these elements; development of programming systems of biochemical computers with functional polymeric capsules; study of hybrid systems, including living organisms, for the applications in unconventional computers.
Traumatic injuries of nervous system represent the leading case of chronic impairment and mortality. Our research efforts are focused on investigation of traumatic spinal cord and brain injuries and on targeting the basic mechanisms of motor control. Ability to reactivate damaged components of neuronal networks requires multidisciplinary approaches and we focus on the most effective ways to activate spinal networks with electrical stimulation, pharmacology, and peripheral stimulation, to promote neuroplasticity and synaptic connectivity. Our methods combine animal experiments, clinical studies, engineering, biomechanics and biochemical techniques. Members of our team combine critical expertise in biological science, bioengineering, and medical research.